公开(公告)号：US20210369716A1

公开(公告)日：2021-12-02

申请号：US17398852

申请日：2021-08-10

Applicant: NOVARTIS AG

Inventor： Agnes BIGGART ,  Fang LIANG ,  Casey Jacob Nelson MATHISON ,  Valentina MOLTENI ,  Advait Suresh NAGLE ,  Frantisek SUPEK ,  Vince YEH

IPC: A61K31/519 ,  C07D487/04 ,  C07D519/00 ,  C07F5/02 ,  C07F7/08 ,  A61K31/5377 ,  A61K31/695 ,  A61K45/06

Abstract: The present invention provides compounds of Formula A: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as leishmaniasis, human African trypanosomiasis and Chagas disease.

公开(公告)号：US20200179391A1

公开(公告)日：2020-06-11

申请号：US16780628

申请日：2020-02-03

Applicant: NOVARTIS AG

Inventor： Agnes BIGGART ,  Fang LIANG ,  Casey Jacob Nelson MATHISON ,  Valentina MOLTENI ,  Advait Suresh NAGLE ,  Frantisek SUPEK ,  Vince YEH

IPC: A61K31/519 ,  A61K45/06 ,  A61K31/695 ,  A61K31/5377 ,  C07F7/08 ,  C07F5/02 ,  C07D519/00 ,  C07D487/04

Abstract: The present invention provides compounds of Formula A: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as leishmaniasis, human African trypanosomiasis and Chagas disease.

公开(公告)号：US20190000852A1

公开(公告)日：2019-01-03

申请号：US16116418

申请日：2018-08-29

Applicant: NOVARTIS AG

Inventor： Agnes BIGGART ,  Fang LIANG ,  Casey Jacob Nelson MATHISON ,  Valentina MOLTENI ,  Advait Suresh NAGLE ,  Frantisek SUPEK ,  Vince YEH

IPC: A61K31/519 ,  A61K45/06 ,  A61K31/695 ,  A61K31/5377

Abstract: The present invention provides compounds of Formula A: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as leishmaniasis, human African trypanosomiasis and Chagas disease.

公开(公告)号：US20180230145A1

公开(公告)日：2018-08-16

申请号：US15889578

申请日：2018-02-06

Applicant: NOVARTIS AG

Inventor： Arnab Kumar CHATTERJEE ,  Advait Suresh NAGLE ,  Prasuna PARASELLI ,  Ravinder Reddy KONDREDDI ,  Seh Yong LEONG ,  Pranab Kumar MISHRA ,  Robert Joseph MOREAU ,  Jason Thomas ROLAND ,  Wei Lin Sandra SIM ,  Oliver SIMON ,  Liying Jocelyn TAN ,  Bryan KS YEUNG ,  Bin ZOU ,  Venkatataiah BOLLU

IPC: C07D471/04 ,  C07D519/00 ,  A61K45/06 ,  A61K31/437 ,  A61K31/506 ,  A61K31/538

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K31/506 ,  A61K31/538 ,  A61K45/06 ,  C07D519/00 ,  Y02A50/411

Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.