公开(公告)号：US20150164897A1

公开(公告)日：2015-06-18

申请号：US14414998

申请日：2013-07-25

Applicant: NOVARTIS AG

Inventor： Giordano Caponigro ,  Darrin Stuart ,  Sunkyu Kim ,  Alice Loo ,  Scott Delach

IPC: A61K31/519 ,  A61K31/4184 ,  A61K31/506

CPC classification number: A61K31/519 ,  A61K31/4184 ,  A61K31/506 ,  A61K2300/00

Abstract: A pharmaceutical combination comprising (a) CDK4/6 inhibitor (b) a B-Raf inhibitor, and optionally (c) a MEK 1/2 inhibitor; combined preparations and pharmaceutical compositions thereof; the uses of such combination in the treatment of proliferative diseases; and methods of treating a subject suffering from a proliferative disease comprising administering a therapeutically effective amount of such combination.

Abstract translation: 一种药物组合，其包含（a）CDK4 / 6抑制剂（b）B-Raf抑制剂和任选的（c）MEK 1/2抑制剂; 联合制剂及其药物组合物; 这种组合在增殖性疾病治疗中的应用; 以及治疗患有增殖性疾病的受试者的方法，包括施用治疗有效量的这种组合。

公开(公告)号：US09700557B2

公开(公告)日：2017-07-11

申请号：US14414998

申请日：2013-07-25

Applicant: NOVARTIS AG

Inventor： Giordano Caponigro ,  Darrin Stuart ,  Sunkyu Kim ,  Alice Loo ,  Scott Delach

IPC: A61K31/519 ,  A61K31/4184 ,  A61K31/506

CPC classification number: A61K31/519 ,  A61K31/4184 ,  A61K31/506 ,  A61K2300/00

Abstract: A pharmaceutical combination comprising (a) CDK4/6 inhibitor (b) a B-Raf inhibitor, and optionally (c) a MEK 1/2 inhibitor; combined preparations and pharmaceutical compositions thereof; the uses of such combination in the treatment of proliferative diseases; and methods of treating a subject suffering from a proliferative disease comprising administering a therapeutically effective amount of such combination.