公开(公告)号：US20220025070A1

公开(公告)日：2022-01-27

申请号：US17309713

申请日：2019-12-17

Applicant: NOVARTIS AG

Inventor： Stefan EWERT ,  Andrew GREEN ,  Alexander Wolfgang KOCH

IPC: C07K16/42

Abstract: The present disclosure relates to reversal agents, which specifically bind to anti-Factor XI and/or anti-Factor XIa antibodies (e.g., NOV1401), and reverse one or more anticoagulant effects of the anti-Factor XI and/or anti-Factor XIa antibodies (e.g., NOV1401), as well as to methods of use thereof, such as methods for reversing anticoagulant effects of such anti-Factor XI and/or anti-Factor XIa antibodies (e.g., NOV1401), and to related methods for managing bleeding or bleeding risks.