公开(公告)号：US11453651B2

公开(公告)日：2022-09-27

申请号：US15895224

申请日：2018-02-13

Applicant: NOVARTIS AG

Inventor： Birgit Bollbuck ,  Christian Markert ,  Wolfgang Miltz ,  Till Roehn

IPC: A61K31/41 ,  A61K31/415 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/428 ,  C07D231/12 ,  C07D271/10 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12 ,  C07D257/04 ,  A61K45/06 ,  A61K31/4439

Abstract: The present invention describes novel heteroaryl butanoic acid derivatives that are good drug candidates especially with regard to leukotriene A4 hydrolase (LTA4H). The present invention also relates to pharmaceutical compositions comprising said novel heteroaryl butanoic acid derivatives, methods of using said compounds in the treatment of various diseases and disorders, and processes for preparing the said novel compounds.