公开(公告)号：US10537563B2

公开(公告)日：2020-01-21

申请号：US16341075

申请日：2017-10-13

Applicant: NOVARTIS AG

Inventor： Christopher Adams ,  Muneto Mogi ,  Stephen Hedrick Poor ,  Timothy Michael Ramsey ,  Henry Wu ,  Qin Zhang

IPC: A61K31/4427 ,  A61K31/4439 ,  A61P27/02 ,  A61K9/00

Abstract: The present invention provides in one aspect methods for treating ocular diseases by administering pharmaceutical compositions comprising an inhibitor of colony stimulating factor-1 (CSF-1) receptors. In another aspect, the present invention provides pharmaceutical compositions for treating ocular diseases, the compositions comprising at least one inhibitor of CSF-1R. The inhibitor can also be a selective inhibitor of CSF-1R in certain embodiments.

公开(公告)号：US10316020B2

公开(公告)日：2019-06-11

申请号：US16063059

申请日：2016-12-16

Applicant: NOVARTIS AG

Inventor： Christopher Adams ,  Takeru Ehara

IPC: C07D401/14 ,  C07D401/10 ,  A61K31/454 ,  C07D401/12 ,  A61P27/06

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.