公开(公告)号：US20190055219A1

公开(公告)日：2019-02-21

申请号：US16045993

申请日：2018-07-26

Applicant: NOVARTIS AG

Inventor： John Ryan Kerrigan ,  Natalie Dales ,  George Scott Tria ,  Daniel Palacios ,  Paul Gormisky

IPC: C07D401/14 ,  C07D405/14 ,  C07D403/12 ,  C07D471/04 ,  C07D498/04 ,  C07D403/14

Abstract: The present disclosure provides a compound of formula (I): or a pharmaceutically acceptable salt thereof, and its therapeutic uses for activating a growth factor pathway, promoting wound healing, promoting tissue repair, and treating hearing loss, skeletal muscle loss, organ degeneration, tissue damage, neurodegeneration, and muscular atrophy. The disclosure further provides pharmaceutical compositions and combinations. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

公开(公告)号：US10654828B2

公开(公告)日：2020-05-19

申请号：US16045993

申请日：2018-07-26

Applicant: NOVARTIS AG

Inventor： John Ryan Kerrigan ,  Natalie Dales ,  George Scott Tria ,  Daniel Palacios ,  Paul Gormisky

IPC: C07D401/14 ,  C07D405/14 ,  C07D403/14 ,  C07D471/04 ,  C07D487/04 ,  C07D403/04 ,  A61P25/28 ,  C07D471/08 ,  C07D491/04 ,  A61P21/00 ,  A61P27/16 ,  C07D403/12 ,  C07D498/04

Abstract: The present disclosure provides a compound of formula (I): or a pharmaceutically acceptable salt thereof, and its therapeutic uses for activating a growth factor pathway, promoting wound healing, promoting tissue repair, and treating hearing loss, skeletal muscle loss, organ degeneration, tissue damage, neurodegeneration, and muscular atrophy. The disclosure further provides pharmaceutical compositions and combinations. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.