公开(公告)号：US20210347784A1

公开(公告)日：2021-11-11

申请号：US17368537

申请日：2021-07-06

Applicant: NOVARTIS AG

Inventor： Ha-Soon CHOI ,  Jiqing JIANG ,  James Paul LAJINESS ,  Bao NGUYEN ,  Hank Michael James Petrassi

IPC: C07D493/08 ,  A61K9/00 ,  A61K31/343

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds; and methods of using such compounds for treating joint damage or injury in a mammal, for inducing hyaline cartilage production or for inducing differentiation of chondrogenic progenitor cells into mature chondrocytes.

公开(公告)号：US20230365580A1

公开(公告)日：2023-11-16

申请号：US18354163

申请日：2023-07-18

Applicant: NOVARTIS AG

Inventor： Ha-Soon CHOI ,  Jiqing JIANG ,  James Paul LAJINESS ,  Bao NGUYEN ,  Hank Michael James PETRASSI

IPC: C07D493/08 ,  A61K9/00 ,  A61K31/343

CPC classification number: C07D493/08 ,  A61K9/0053 ,  A61K31/343

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof;




or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds; and methods of using such compounds for treating joint damage or injury in a mammal, for inducing hyaline cartilage production or for inducing differentiation of chondrogenic progenitor cells into mature chondrocytes.

公开(公告)号：US20210079010A1

公开(公告)日：2021-03-18

申请号：US16620407

申请日：2018-06-07

Applicant: NOVARTIS AG

Inventor： Ha-Soon CHOI ,  Jiqing JIANG ,  James Paul LAJINESS ,  Bao NGUYEN ,  Hank Michael James Petrassi

IPC: C07D493/08 ,  A61K31/343 ,  A61K9/00

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; (I) or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds; and methods of using such compounds for treating joint damage or injury in a mammal, for inducing hyaline cartilage production or for inducing differentiation of chondrogenic progenitor cells into mature chondrocytes.