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公开(公告)号：US20190382441A1
公开(公告)日：2019-12-19
申请号：US16439204
申请日：2019-06-12
Applicant: NOVARTIS AG
Inventor： Bernhard Hubert GEIERSTANGER , Jan GRUNEWALD , Yunho JIN , Weijia OU , Tetsuo UNO , Yongqin WAN , Xing WANG
Abstract: Disclosed herein are novel cytotoxic peptides of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel cytotoxic peptide linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.
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公开(公告)号：US20180244717A1
公开(公告)日：2018-08-30
申请号：US15961531
申请日：2018-04-24
Applicant: NOVARTIS AG
Inventor： Bernhard Hubert GEIERSTANGER , Jan GRUNEWALD , Yunho JIN , Weijia OU , Tetsuo UNO , Yongqin WAN , Xing WANG
CPC classification number: C07K5/0205 , A61K47/6817 , A61K47/6851 , C07K7/02 , C07K16/32
Abstract: Disclosed herein are novel cytotoxic peptides of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel cytotoxic peptide linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.
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