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公开(公告)号:US10130629B2
公开(公告)日:2018-11-20
申请号:US15561209
申请日:2016-03-23
Applicant: Novartis AG
Inventor: Nicole Buschmann , Robin Alec Fairhurst , Jorge Garcia Fortanet , Pascal Furet , Diana Graus Porta , Nafeeza Hafeez , Bo Han , Thomas Knoepfel , Matthew J. LaMarche , Catherine Leblanc , Lv Liao , Robert Mah , Dale Porter , Can Wang , Markus Wartmann , Jing Xiong , Xianglin Zhao
IPC: A61K31/496 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/519 , A61K31/5377
Abstract: A pharmaceutical combination comprising N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide, or a pharmaceutically acceptable salt thereof, and at least one active ingredient, as defined herein, or a pharmaceutically acceptable salt thereof, and optionally a pharmaceutically acceptable carrier, for simultaneous or sequential administration; the uses of such combination in the treatment of proliferative diseases; and methods of treating a subject suffering from a proliferative disease comprising administering a therapeutically effective amount of such combination.
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公开(公告)号:US10507201B2
公开(公告)日:2019-12-17
申请号:US16289612
申请日:2019-02-28
Applicant: NOVARTIS AG
Inventor: Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Diana Graus Porta , Carolina Haefliger , Bo Han , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Masato Murakami , Pierre Nimsgern , Michael Palmer , Dale Porter , Sebastien Ripoche , Can Wang , Youzhen Wang , Andreas Weiss , Jing Xiong , Xianglin Zhao
IPC: A61K31/475 , A61K31/4545 , A61K31/496 , A61K31/55 , A61P35/00 , A61K31/4375
Abstract: The present invention relates to therapeutic uses of compounds of formula (I) or a pharmaceutically acceptable salt thereof
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公开(公告)号:US10463653B2
公开(公告)日:2019-11-05
申请号:US16190087
申请日:2018-11-13
Applicant: NOVARTIS AG
Inventor: Lv Liao , Jing Xiong
IPC: A61K31/4375 , A61K31/4545 , A61K31/496 , A61P35/00 , A61K31/55
Abstract: The present invention relates to therapeutic uses of compounds of formula (1) or a pharmaceutically acceptable salt thereof.
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