公开(公告)号：US20200261456A1

公开(公告)日：2020-08-20

申请号：US16789963

申请日：2020-02-13

Applicant: NOVARTIS AG

Inventor： Quintus MEDLEY ,  Muneto MOGI ,  Michela MONTECCHI-PALMER ,  Kali STASI

IPC: A61K31/517

Abstract: The present invention provides methods for treating ocular surface pain by administering 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I). The present invention also provides methods for treating dry eye disease and ocular hyperemia by administering 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile.

公开(公告)号：US20200261457A1

公开(公告)日：2020-08-20

申请号：US16789976

申请日：2020-02-13

Applicant: NOVARTIS AG

Inventor： Joseph Paul BULLOCK ,  Chinmay MAHESHWARI ,  Quintus MEDLEY ,  Muneto MOGI ,  Michela MONTECCHI-PALMER ,  Kali STASI

IPC: A61K31/517 ,  A61K47/38 ,  A61K47/02 ,  A61K47/26 ,  A61K47/10

Abstract: The present invention provides formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I) and methods for treating ocular surface pain by administering such formulations. The present invention also provides methods for treating dry eye disease and ocular hyperemia by administering formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile.