公开(公告)号：US11406627B2

公开(公告)日：2022-08-09

申请号：US16754539

申请日：2018-10-11

Applicant: NOVARTIS AG

Inventor： Giordano Caponigro ,  Ensar Halilovic ,  Kelli-Ann Monaco

IPC: A61K31/4439 ,  A61P35/00 ,  A61K31/4965

Abstract: The present invention relates to a pharmaceutical combination comprising (a) an MDM2 inhibitor and (b) an ERK inhibitor, for use in the treatment of a cancer. This invention relates to uses of such combination for preparation of a medicament for the treatment of a cancer; methods of treating a cancer in a subject in need thereof comprising administering to said subject a jointly therapeutically effective amount of said combination; pharmaceutical compositions comprising such combination; and kits and/or packages containing such combinations.

公开(公告)号：US20200281910A1

公开(公告)日：2020-09-10

申请号：US16754539

申请日：2018-10-11

Applicant: NOVARTIS AG

Inventor： Giordano Caponigro ,  Ensar Halilovic ,  Kelli-Ann Monaco

IPC: A61K31/4439 ,  A61K31/4965 ,  A61P35/00

Abstract: The present invention relates to a pharmaceutical combination comprising (a) an MDM2 inhibitor and (b) an ERK inhibitor, for use in the treatment of a cancer. This invention relates to uses of such combination for preparation of a medicament for the treatment of a cancer; methods of treating a cancer in a subject in need thereof comprising administering to said subject a jointly therapeutically effective amount of said combination; pharmaceutical compositions comprising such combination; and kits and/or packages containing such combinations.