公开(公告)号：US20210340205A1

公开(公告)日：2021-11-04

申请号：US17266828

申请日：2019-08-09

Applicant: NOVARTIS AG

Inventor： Jirong BAI ,  Kurt Alex HELDWEIN ,  Loren Daniel LINDSLEY

IPC: C07K14/495 ,  G01N33/68 ,  G01N33/566 ,  C07K16/22 ,  C07K16/28 ,  C07K14/71

Abstract: GFRAL extracellular domains comprising domains D2 and D3 are disclosed. The disclosure further relates to methods and compositions for screening and evaluating the activity of a GFRAL ligand, such as a GDF15 peptide, using the GFRAL extracellular domains provided herein. Also disclosed are methods and compositions for treating obesity, reducing appetite, and/or reducing body weight using the GFRAL extracellular domains provided herein.