公开(公告)号：US11878060B2

公开(公告)日：2024-01-23

申请号：US16323319

申请日：2017-08-04

Applicant: NOVARTIS AG

Inventor： John Dominy ,  Robert Dunn ,  Scott Glaser ,  Mark Keating ,  Carla Klattenhoff ,  Igor Splawski

IPC: A61K47/54 ,  C07K16/28 ,  C07K16/22

CPC classification number: A61K47/549 ,  A61K47/543 ,  C07K16/22 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/2851 ,  C07K2317/24

Abstract: The present disclosure is directed to methods of immunization and methods for generating antibodies using compositions comprising cationic lipids and polynucleotide molecules, such as polyribonucleotide molecules, e.g., mRNA, which code for immunogens (e.g., a target protein or a fragment thereof).