公开(公告)号：US20150191513A1

公开(公告)日：2015-07-09

申请号：US14420937

申请日：2013-08-29

Applicant: NOVARTIS AG

Inventor： Fabio Bagnoli ,  Matthew Bottomley ,  Guido Grandi ,  Mikkel Nissum ,  Michele Pallaoro ,  Silvana Savino

IPC: C07K14/31 ,  A61K39/085

CPC classification number: C07K14/31 ,  A61K39/085 ,  A61K2039/55505

Abstract: Elimination of disulphide bond formation of cysteine-containing S. aureus antigens enhances antigen stability. The invention provides variant forms of cysteine-containing S. aureus antigen with a point mutation that replaces, deletes or modifies the cysteine residue.