公开(公告)号：US09522149B2

公开(公告)日：2016-12-20

申请号：US14690513

申请日：2015-04-20

Applicant: NOVARTIS AG

Inventor： Gurdip Bhalay ,  Lee Edwards ,  Catherine Howsham ,  Peter Hunt ,  Nichola Smith

IPC: A61K31/497 ,  C07D471/10

CPC classification number: A61K31/497 ,  C07D471/10

Abstract: Compounds of Formula I: and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 have the meanings as indicated in the specification, are useful for treating diseases mediated by blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

公开(公告)号：US09050339B2

公开(公告)日：2015-06-09

申请号：US13657001

申请日：2012-10-22

Applicant: NOVARTIS AG

Inventor： Gurdip Bhalay ,  Lee Edwards ,  Catherine Howsham ,  Peter Hunt ,  Nichola Smith

IPC: A61K31/497 ,  C07D241/10 ,  C07D471/10

CPC classification number: A61K31/497 ,  C07D471/10

Abstract: Compounds of Formula I: and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 have the meanings as indicated in the specification, are useful for treating diseases mediated by blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Abstract translation: 式I化合物及其药学上可接受的盐和溶剂合物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9和R10具有说明书中所示的含义，可用于治疗由 阻断上皮钠通道。 还描述了含有化合物的药物组合物和用于制备化合物的方法。