公开(公告)号：US20240067750A1

公开(公告)日：2024-02-29

申请号：US18157312

申请日：2023-01-20

Applicant: NOVARTIS AG

Inventor： Jorg EDER ,  Stefan EWERT ,  Ulrich HASSIEPEN ,  Yasser KHDER ,  Lorenz MAYR ,  Samu MELKKO ,  Nikolaus SCHIERING

IPC: C07K16/36 ,  A61K39/395 ,  A61K45/06 ,  A61P7/02 ,  C07K16/40

CPC classification number: C07K16/36 ,  A61K39/3955 ,  A61K45/06 ,  A61P7/02 ,  C07K16/40 ,  A61K2039/505

Abstract: The present invention relates to monoclonal antibodies and antigen binding fragments thereof that bind to human Factor XI and activated Factor XI (“Factor XIa”), and pharmaceutical compositions and methods of treatment comprising the same.