公开(公告)号：US11930837B2

公开(公告)日：2024-03-19

申请号：US17403710

申请日：2021-08-16

Applicant: NOVARTIS AG

Inventor： Yaiza Diaz-De-Durana ,  Michael DiDonato ,  Christophe Filippi ,  Shelly Meeusen ,  Glen Spraggon

IPC: A61K38/20 ,  A23L7/10 ,  A23L7/104 ,  B02B1/04 ,  B02C4/06 ,  B02C4/16 ,  B02C9/00 ,  B02C23/18 ,  B02C23/40 ,  C07K16/46 ,  B02C15/14

CPC classification number: A23L7/197 ,  A23L7/104 ,  A61K38/2013 ,  B02B1/04 ,  B02C4/06 ,  B02C4/16 ,  B02C9/00 ,  B02C23/18 ,  B02C23/40 ,  C07K16/46 ,  A23V2002/00 ,  B02C15/14

Abstract: The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through a high affinity interleukin receptor. The antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prevention of immune related disorders such as Type 1 Diabetes.

公开(公告)号：US20220346415A1

公开(公告)日：2022-11-03

申请号：US17813232

申请日：2022-07-18

Applicant: NOVARTIS AG

Inventor： Yaiza Diaz-De-Durana ,  Michael DiDonato ,  Christophe Filippi ,  Shelly Meeusen ,  Glen Spraggon

IPC: A23L7/10 ,  A23L7/104 ,  A61K38/20 ,  B02B1/04 ,  B02C4/06 ,  B02C4/16 ,  B02C9/00 ,  B02C23/18 ,  B02C23/40 ,  C07K16/46

Abstract: The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through a high affinity interleukin receptor. The antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prevention of immune related disorders such as Type 1 Diabetes.

公开(公告)号：US11122825B2

公开(公告)日：2021-09-21

申请号：US16616138

申请日：2018-05-22

Applicant: NOVARTIS AG

Inventor： Yaiza Diaz-De-Durana ,  Michael DiDonato ,  Christophe Filippi ,  Shelly Meeusen ,  Glen Spraggon

IPC: A61K38/20 ,  A23L7/10 ,  A23L7/104 ,  B02C4/16 ,  B02C4/06 ,  B02C23/40 ,  B02B1/04 ,  B02C9/00 ,  B02C23/18 ,  C07K16/46 ,  B02C15/14

Abstract: The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through a high affinity interleukin receptor. The antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prevention of immune related disorders such as Type 1 Diabetes.