公开(公告)号：US11203595B2

公开(公告)日：2021-12-21

申请号：US16941395

申请日：2020-07-28

Applicant: NOVARTIS AG

Inventor： Badry Bursulaya ,  Andreas Fisch ,  James Paul Lajiness ,  Rainer Machauer ,  Swapnil Malekar ,  Hank Michael James Petrassi ,  Farshad Ramazani ,  Anne-Catherine Remond ,  Thomas Ullrich ,  Peggy Usselmann ,  Eric Vangrevelinghe

IPC: C07D471/04 ,  A61K9/19 ,  A61P21/00 ,  A61K9/00 ,  A61K9/50 ,  A61K31/437 ,  A61K31/496 ,  A61K31/538

Abstract: The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US10112907B2

公开(公告)日：2018-10-30

申请号：US15711984

申请日：2017-09-21

Applicant: NOVARTIS AG

Inventor： Badry Bursulaya ,  Andreas Fisch ,  James Paul Lajiness ,  Rainer Machauer ,  Swapnil Malekar ,  Hank Michael James Petrassi ,  Farshad Ramazani ,  Anne-Catherine Remond ,  Thomas Ullrich ,  Peggy Usselmann ,  Eric Vangrevelinghe

IPC: A61K31/416 ,  C07D231/56 ,  A61K9/00 ,  A61K9/16 ,  A61K31/454 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12

Abstract: The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US10766894B2

公开(公告)日：2020-09-08

申请号：US16335496

申请日：2017-09-21

Applicant: NOVARTIS AG

Inventor： Badry Bursulaya ,  Andreas Fisch ,  James Paul Lajiness ,  Rainer Machauer ,  Swapnil Malekar ,  Hank Michael James Petrassi ,  Farshad Ramazani ,  Anne-Catherine Remond ,  Thomas Ullrich ,  Peggy Usselmann ,  Eric Vangrevelinghe

IPC: C07D471/04 ,  A61P21/00 ,  A61K9/00 ,  A61K9/50 ,  A61K31/437 ,  A61K31/496 ,  A61K31/538

Abstract: The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.