公开(公告)号：US20180185286A1

公开(公告)日：2018-07-05

申请号：US15301221

申请日：2015-03-31

Applicant: NOVARTIS PHARMA AG ,  MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： Allan Stuart Myerson ,  Xiaochuan Yang ,  Marcus O'Mahony ,  Markus Krumme ,  Norbert Rasenack ,  Leia Dwyer

IPC: A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K31/192 ,  A61K31/216 ,  A61K31/343 ,  A61K9/16

CPC classification number: A61K9/143 ,  A61K9/146 ,  A61K9/1652 ,  A61K9/1694 ,  A61K9/2009 ,  A61K9/485 ,  A61K31/192 ,  A61K31/216 ,  A61K31/277 ,  A61K31/343 ,  A61K31/397 ,  A61K31/405 ,  A61K31/4196 ,  A61K31/4422 ,  A61K31/496 ,  A61K31/64

Abstract: Materials containing pharmaceutically active species in solid (e.g., crystal) form, and related methods, are provided, allowing for improved stability, solubility, bioavailability, and/or dissolution rates for pharmaceutically active species having poor aqueous solubility.