公开(公告)号：US20020168723A1

公开(公告)日：2002-11-14

申请号：US10126617

申请日：2002-04-22

申请人： NPS Allelix Corp.

发明人： Rajender Kamboj ,  Candace E. Elliott ,  Stephen L. Nutt

IPC分类号： C07K014/705 ,  C07H021/04 ,  G01N033/567 ,  C12P021/02 ,  C12N005/06

CPC分类号： C07K14/70571

摘要： Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for one family of these receptors of the kainate-binding type of EAA receptors, has now been isolated and the receptor protein characterized. Herein described are recombinant cell lines which produce the EAA receptor as a heterologous membrane-bound product. Also described are related aspects of the invention, which are of commercial significance. Included is use of the cell lines as a tool for discovery of compounds which modulate EAA receptor stimulation.

摘要翻译： 兴奋性氨基酸（EAAs）如谷氨酸的神经传递通过膜结合表面受体介导。 已经分离了编码红藻氨酸结合型EAA受体的这些受体的一个家族的DNA，并且以受体蛋白为特征。 本文描述了产生作为异源膜结合产物的EAA受体的重组细胞系。 还描述了具有商业意义的本发明的相关方面。 包括使用细胞系作为发现调节EAA受体刺激的化合物的工具。

公开(公告)号：US20030053993A1

公开(公告)日：2003-03-20

申请号：US10121675

申请日：2002-04-15

申请人： NPS ALLELIX CORP.

发明人： Rajender Kamboj ,  Candace E. Elliott ,  Stephen L. Nutt

IPC分类号： A61K048/00 ,  C07H021/04 ,  C07K014/705 ,  C12P021/02 ,  C12N005/06

CPC分类号： C07K14/70571 ,  A61K48/00

摘要： Described herein are isolated polynucleotides which code for an AMPA-type human CNS receptor, designated the human GluR4B receptor. The receptor is characterized structurally and the construction and use of cell lines expressing the receptor is disclosed.