公开(公告)号：US20230183185A1

公开(公告)日：2023-06-15

申请号：US18054272

申请日：2022-11-10

申请人： NUFROMIX TECHNOLOGIES LIMITED

发明人： Joanne HOLLAND ,  Alex EBERLIN

IPC分类号： C07D237/32 ,  C07C65/05 ,  C07C65/03 ,  C07C65/10

CPC分类号： C07D237/32 ,  C07C65/05 ,  C07C65/03 ,  C07C65/10 ,  C07B2200/13

摘要： The invention relates to new 1:1 olaparib:hydroxybenzoic acid cocrystals. The invention also relates to new 2:1 olaparib:hydroxybenzoic acid cocrystals which may contain no water (anhydrous) or may optionally be hydrated. The invention also relates to pharmaceutical compositions containing an olaparib hydroxybenzoic acid cocrystal of the invention and a pharmaceutically acceptable carrier. The olaparib hydroxybenzoic acid cocrystals of the invention may be useful for the treatment of diseases that benefit from inhibition of poly (ADP-ribose) polymerase (PARP).