公开(公告)号：US20180134691A1

公开(公告)日：2018-05-17

申请号：US15843192

申请日：2017-12-15

Applicant: NUHOPE, LLC

Inventor： James R. Connor ,  Sang Yong Lee ,  Thomas James Brown ,  Phillip Martin Cowley

IPC: C07D405/06 ,  C07D403/06 ,  A61K31/513 ,  C07D239/60 ,  C07D401/06

CPC classification number: C07D405/06 ,  A61K31/513 ,  C07D239/60 ,  C07D401/06 ,  C07D403/06

Abstract: Provided are methods and compositions for use in therapy, and in particular for treating cancer, preferably drug-resistant cancer, and/or radiation resistant cancer. The compounds may be used for reducing tumor size in a mammalian subject and for inducing apoptosis in a tumor cell. The methods are effective on tumor cells that are resistant to drugs such as temozolomide, doxorubicin, and geldanamycin, as well as non-resistant tumor cells. Further provided are barbiturate and thiobarbiturates diene compounds for use in treating cancer, and uses, methods and compositions relating to these compounds.

公开(公告)号：US09994554B2

公开(公告)日：2018-06-12

申请号：US15843192

申请日：2017-12-15

Applicant: NUHOPE, LLC

Inventor： James R. Connor ,  Sang Yong Lee ,  Thomas James Brown ,  Phillip Martin Cowley

IPC: C07D405/06 ,  C07D239/60 ,  C07D401/06 ,  A61K31/513 ,  C07D403/06

CPC classification number: C07D405/06 ,  A61K31/513 ,  C07D239/60 ,  C07D401/06 ,  C07D403/06

Abstract: Provided are methods and compositions for use in therapy, and in particular for treating cancer, preferably drug-resistant cancer, and/or radiation resistant cancer. The compounds may be used for reducing tumor size in a mammalian subject and for inducing apoptosis in a tumor cell. The methods are effective on tumor cells that are resistant to drugs such as temozolomide, doxorubicin, and geldanamycin, as well as non-resistant tumor cells. Further provided are barbiturate and thiobarbiturates diene compounds for use in treating cancer, and uses, methods and compositions relating to these compounds.