公开(公告)号：US20020090341A1

公开(公告)日：2002-07-11

申请号：US09975317

申请日：2001-10-12

申请人： NYCOMED IMAGING AS

发明人： Alan David Watson ,  Michael Wendland ,  Per Jynge ,  Jan Olof Karlsson ,  Heidi Brurok ,  Pal Rongved ,  Maythem Saeed

IPC分类号： A61K049/00

CPC分类号： G01R33/5601 ,  A61K49/06

摘要： The invention provides a method of detecting myocardial ischemia in a human or a non-human body, said method comprising administering to said body a physiologically acceptable manganese complex or salt thereof, subjecting said body to a magnetic resonance imaging procedure capable of generating images with time intervals of less than 0.5 seconds and thereafter providing a series of images of the myocardium of said body whereby to identify regions of abnormal blood flow. The method in accordance with the invention is of use not only in detecting myocardial ischemia, but also in discriminating between reversibly and irreversibly injured myocardial tissues, thereby providing important information about myocardial viability, e.g. during or following a severe heart attack or coronary occlusion. The method of the invention also provides an effective means of monitoring reperfusion of the myocardium.

摘要翻译： 本发明提供了一种在人或非人体中检测心肌缺血的方法，所述方法包括向所述身体施用生理上可接受的锰络合物或其盐，使所述身体进行能够随时间产生图像的磁共振成像程序 间隔小于0.5秒，此后提供所述身体的心肌的一系列图像，从而识别异常血流的区域。 根据本发明的方法不仅用于检测心肌缺血，还用于区分可逆和不可逆损伤的心肌组织，从而提供关于心肌存活力的重要信息，例如， 在严重心脏病发作或冠状动脉闭塞期间或之后。 本发明的方法还提供了监测心肌再灌注的有效手段。