公开(公告)号：US20140296492A1

公开(公告)日：2014-10-02

申请号：US14299509

申请日：2014-06-09

申请人： Nai-Kong CHEUNG ,  Dimiter Tassev ,  Jian Hu

发明人： Nai-Kong CHEUNG ,  Dimiter Tassev ,  Jian Hu

IPC分类号： C07K16/28

CPC分类号： C07K16/2833 ,  A61K2039/505 ,  C07K16/085 ,  C07K16/18 ,  C07K2317/31 ,  C07K2317/32 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/92 ,  C07K2319/00

摘要： Antigen binding proteins with TCR-like paratopes, that is, with an antigen binding region specific for an HLA-A2 restricted peptide are disclosed. The antigen binding proteins encompass antibodies in a variety of forms, including full-length antibodies, substantially intact antibodies, Fab fragments, F(ab′)2 fragments, and single chain Fv fragments. Fusion proteins, such as scFv fusions with immunoglobulin or T-cell receptor domains, incorporating the specificity of the antigen binding region for each peptide are also contemplated by the invention. Furthermore, immunoconjugates may include antibodies to which is linked a radioisotope, fluorescent or other detectable marker, cytotoxin, or other molecule are also encompassed by the invention. Among other things, immunoconjugates can be used for delivery of an agent to elicit a therapeutic effect or to facilitate an immune effector function.

摘要翻译： 公开了具有TCR样相互作用的抗原结合蛋白，即具有HLA-A2限制性肽特异性的抗原结合区。 抗原结合蛋白包括多种形式的抗体，包括全长抗体，基本上完整的抗体，Fab片段，F（ab'）2片段和单链Fv片段。 本发明还考虑融合蛋白，例如与免疫球蛋白或T细胞受体结构域的融合蛋白融合蛋白抗原结合区域的特异性。 此外，免疫缀合物可以包括与放射性同位素，荧光或其他可检测标记，细胞毒素或其它分子连接的抗体也包括在本发明中。 除其他之外，免疫缀合物可用于递送药剂以引发治疗效果或促进免疫效应子功能。