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公开(公告)号：US08071768B2
公开(公告)日：2011-12-06
申请号：US11422349
申请日：2006-06-06
申请人： Nand Baindur , Michael David Gaul , Kevin Douglas Kreutter , Christian Andrew Baumann , Alexander J. Kim , Guozhang Xu , Robert W. Tuman , Dana L. Johnson
发明人： Nand Baindur , Michael David Gaul , Kevin Douglas Kreutter , Christian Andrew Baumann , Alexander J. Kim , Guozhang Xu , Robert W. Tuman , Dana L. Johnson
IPC分类号： C07D401/00 , C07D413/00
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula I: wherein R1, R2, R3, B, Z, G, Q and X are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of FLT3 and/or c-kit and/or TrkB, the use of such compounds to reduce or inhibit kinase activity of FLT3 and/or c-kit and/or TrkB in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to FLT3 and/or c-kit and/or TrkB. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
摘要翻译： 本发明涉及式I的烷基喹啉和烷基喹唑啉化合物：其中R 1，R 2，R 3，B，Z，G，Q和X如本文所定义，使用这些化合物作为蛋白质酪氨酸激酶调节剂，特别是FLT3抑制剂， /或c-kit和/或TrkB，使用这些化合物降低或抑制细胞或受试者中FLT3和/或c-kit和/或TrkB的激酶活性，以及使用这些化合物预防或治疗 在受试者中是与FLT3和/或c-kit和/或TrkB相关的细胞增殖性病症和/或病症。 本发明进一步涉及包含本发明化合物的药物组合物和治疗诸如癌症和其它细胞增殖性疾病的病症的方法。
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2.发明授权Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis 有权用于合成烷基喹啉和烷基喹唑啉激酶调节剂的中间体及其相关合成方法公开(公告)号：US07825244B2
公开(公告)日：2010-11-02
申请号：US11422352
申请日：2006-06-06
IPC分类号： C07D239/88 , C07D239/94 , C07D215/12 , C07D215/14
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14
摘要： The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: wherein R1, R2, R99, and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.
摘要翻译： 本发明涉及式C的烷基喹啉和烷基喹唑啉化合物：其中R1，R2，R99和X如本文所定义，这些化合物在合成蛋白酪氨酸激酶抑制剂，特别是FLT3和/或c- 套件和/或TrkB。
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公开(公告)号：US20090143378A1
公开(公告)日：2009-06-04
申请号：US12362933
申请日：2009-01-30
IPC分类号： A61K31/5377 , C07D495/04 , A61K31/519
CPC分类号： C07D495/04
摘要： The invention is directed to thienopyrimidines and thienopyridines compounds of Formula I and Formula II: where R1, R3, B, Z, Q, p, q and X are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of FLT3, the use of such compounds to reduce or inhibit kinase activity of FLT3 in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to FLT3. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
摘要翻译： 本发明涉及式I和式II的噻吩并嘧啶和噻吩并吡啶化合物：其中R1，R3，B，Z，Q，p，q和X如本文所定义，使用这些化合物作为蛋白质酪氨酸激酶调节剂，特别是抑制剂 FLT3的使用，使用这些化合物降低或抑制细胞或受试者中FLT3的激酶活性，以及这些化合物在受试者中预防或治疗细胞增殖性疾病和/或与FLT3相关的疾病的用途。 本发明进一步涉及包含本发明化合物的药物组合物和治疗诸如癌症和其它细胞增殖性疾病的病症的方法。
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公开(公告)号：US20090163710A1
公开(公告)日：2009-06-25
申请号：US12363043
申请日：2009-01-30
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： The invention is directed to thienopyrimidines and thienopyridines compounds of Formula I and Formula II: where R1, R3, B, Z, Q, p, q and X are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of FLT3, the use of such compounds to reduce or inhibit kinase activity of FLT3 in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to FLT3. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
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