公开(公告)号：US20230192883A1

公开(公告)日：2023-06-22

申请号：US18015508

申请日：2021-07-16

申请人： Nanjing Legend Biotech Co., Ltd.

发明人： Xiaohu Fan ,  Zhe Zhou ,  Qiuchuan ZHUANG ,  Xu Fang ,  Yue HAN ,  Youguo PENG ,  Manman LU

IPC分类号： C07K16/28 ,  C12N15/63 ,  A61P35/00

CPC分类号： C07K16/2896 ,  A61P35/00 ,  C12N15/63 ,  C07K2317/20 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2319/02 ,  C07K2319/03

摘要： The present disclosure provides single domain antibodies that bind to CD19, and chimeric antigen receptors comprising same. Further provided are engineered immune effector cells (such as T cells) comprising the chimeric antigen receptors. Pharmaceutical compositions, kits and methods of treating a disease or disorder are also provided.