公开(公告)号：US20140303248A1

公开(公告)日：2014-10-09

申请号：US14355340

申请日：2012-10-24

申请人： Nanjing Medical University

发明人： Dongya Zhu ,  Fei Li ,  Chunxia Luo

IPC分类号： C07C229/60

CPC分类号： C07C229/60 ,  A61K31/196 ,  A61K31/245 ,  C07C229/54 ,  C07C233/54 ,  C07C2603/64

摘要： A N-benzylaniline derivative and uses thereof. The derivative is a compound represented by formula I or a pharmaceutically acceptable salt thereof. The compound protects against cerebral ischemia/reperfusion injury and has analgesic action for chronic pathologic pain, and may be used to treat cerebral apoplexy, neuropathic pain, and inflammatory pain. Moreover, because of the unique mechanism of action of the compound, the compound can be used to treat epilepsy, affective disorder, and neurodegenerative diseases.

摘要翻译： N-苄基苯胺衍生物及其用途。 该衍生物是由式I表示的化合物或其药学上可接受的盐。 该化合物可防止脑缺血/再灌注损伤，对慢性病理性疼痛具有镇痛作用，可用于治疗脑中风，神经性疼痛和炎性疼痛。 此外，由于化合物的独特作用机制，该化合物可用于治疗癫痫，情感障碍和神经退行性疾病。

公开(公告)号：US09481636B2

公开(公告)日：2016-11-01

申请号：US14355340

申请日：2012-10-24

申请人： Nanjing Medical University

发明人： Dongya Zhu ,  Fei Li ,  Chunxia Luo

IPC分类号： C07C229/00 ,  C07C229/60 ,  A61K31/196 ,  A61K31/245 ,  C07C233/54 ,  C07C229/54

CPC分类号： C07C229/60 ,  A61K31/196 ,  A61K31/245 ,  C07C229/54 ,  C07C233/54 ,  C07C2603/64

摘要： A N-benzylaniline derivative and uses thereof. The derivative is a compound represented by formula I or a pharmaceutically acceptable salt thereof. The compound protects against cerebral ischemia/reperfusion injury and has analgesic action for chronic pathologic pain, and may be used to treat cerebral apoplexy, neuropathic pain, and inflammatory pain. Moreover, because of the unique mechanism of action of the compound, the compound can be used to treat epilepsy, affective disorder, and neurodegenerative diseases.