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公开(公告)号:US20090054464A1
公开(公告)日:2009-02-26
申请号:US12264363
申请日:2008-11-04
申请人: Naoki ISHIBASHI , Yuki SAWADA , Yasuharu URANO , Shigeki SATOH , Yoshikazu INOUE , Yoshiteru EIKYU , Koichiro MUKOYOSHI , Kazunori KAMIJO , Fumiyuki SHIRAI , Hisashi TAKASUGI
发明人: Naoki ISHIBASHI , Yuki SAWADA , Yasuharu URANO , Shigeki SATOH , Yoshikazu INOUE , Yoshiteru EIKYU , Koichiro MUKOYOSHI , Kazunori KAMIJO , Fumiyuki SHIRAI , Hisashi TAKASUGI
IPC分类号: A61K31/4439 , C07D401/02 , C07D401/14 , C07D417/02 , C07D405/14 , C07D409/14 , A61P33/02 , A61P35/02 , A61K31/497 , A61K31/506 , A61K31/4545 , A61K31/454
CPC分类号: C07D213/74 , C07C259/06 , C07D207/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14
摘要: Compounds having the formula (I): wherein R1 is hydrogen, lower alkyl, lower alkenyl, lower or higher alkynyl, cyclo(lower)alkyl, cyclo(higher)alkyl, cyclo(lower)alkyl(lower)alkyl, cyclo(higher)alkyl(lower)alkyl, cyclo(lower)alkenyl(lower)alkyl, aryl-fused cyclo(lower)alkyl, lower alkoxy, acyl, aryl, ar(lower)alkoxy, ar(lower)alkyl, heteroar(lower)alkyl, amino, heteroaryl, heterocyclyl or heterocyclyl(lower)alkyl, which may be substituted with one or more suitable substituent(s), R2 is hydrogen or lower alkyl, X is pyrrolidinylene or piperidinylene, Y is pyridylene, which may be substituted with one or more suitable substituent(s), Z is lower alkenylene, which may be substituted with lower alkyl or halogen, and salts thereof are useful as a histone deacetylase inhibitors.
摘要翻译: 具有式(I)的化合物:其中R1是氢,低级烷基,低级烯基,低级或高级炔基,环(低级)烷基,环(高级)烷基,环(低级)烷基(低级)烷基, 烷基,低级烷基,低级烷基,低级烷基,低级烷基,低级烷基,低级烷基,低级烷基, 氨基,杂芳基,杂环基或杂环基(低级)烷基,其可以被一个或多个合适的取代基取代,R 2是氢或低级烷基,X是吡咯烷基或哌啶子基,Y是亚吡啶基,其可以被一个或多个 更合适的取代基,Z是低级亚烯基,其可以被低级烷基或卤素取代,其盐可用作组蛋白脱乙酰酶抑制剂。