公开(公告)号：US11845735B2

公开(公告)日：2023-12-19

申请号：US17971959

申请日：2022-10-24

申请人： Nasim Batooie

发明人： Nasim Batooie

IPC分类号： C07D311/56

CPC分类号： C07D311/56

摘要： A method for synthesizing (RS)-Warfarin comprising preparing a liquid mixture, wherein the liquid mixture comprises trihexyltetradecylphosphonium bromide, methyl salicylate, acetyl chloride, benzaldehyde, and acetone. The method may further comprise incubating the liquid mixture at a temperature between 20° C. and 30° C. for a time duration between 26 and 34 minutes, and forming (RS)-Warfarin by adding water to the incubated liquid mixture with a volume ratio (water:incubated liquid mixture) between 1:1 and 1.5:1.

公开(公告)号：US20230167079A1

公开(公告)日：2023-06-01

申请号：US17971959

申请日：2022-10-24

申请人： Nasim Batooie

发明人： Nasim Batooie

IPC分类号： C07D311/56

CPC分类号： C07D311/56

摘要： A method for synthesizing (RS)-Warfarin comprising preparing a liquid mixture, wherein the liquid mixture comprises trihexyltetradecylphosphonium bromide, methyl salicylate, acetyl chloride, benzaldehyde, and acetone. The method may further comprise incubating the liquid mixture at a temperature between 20° C. and 30° C. for a time duration between 26 and 34 minutes, and forming (RS)-Warfarin by adding water to the incubated liquid mixture with a volume ratio (water:incubated liquid mixture) between 1:1 and 1.5:1.

公开(公告)号：US20230111768A1

公开(公告)日：2023-04-13

申请号：US18080744

申请日：2022-12-14

申请人： Nasim Batooie ,  Mohammad Mehdi Khodaei ,  Kiumars Bahrami ,  Seyyed Shahram Miraghaee

发明人： Nasim Batooie ,  Mohammad Mehdi Khodaei ,  Kiumars Bahrami ,  Seyyed Shahram Miraghaee

IPC分类号： C07D513/14 ,  C07D513/04

摘要： A method for synthesizing a compound comprising forming a liquid mixture by adding a CH-acid, 2-Mercaptobenzimidazole, and a benzaldehyde component to an ionic liquid of trihexyltetradecylphosphonium bromide. The method may further comprise mixing the liquid mixture at a temperature between 20° C. and 30° C. for a time duration between 17 and 30 minutes, and forming the compound by adding an ethanol-water solution to the mixed liquid mixture with a volume ratio (ethanol-water solution:mixed liquid mixture) between 1:1 and 1.5:1.