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    Treatment of Prostate Cancer with Angiogenesis-Targeting Quinazoline-Based Anti-Cancer Compounds
    2.
    发明申请
    Treatment of Prostate Cancer with Angiogenesis-Targeting Quinazoline-Based Anti-Cancer Compounds 审中-公开
    用血管发生靶向喹唑啉类抗癌化合物治疗前列腺癌

    公开(公告)号：US20090170865A1

    公开(公告)日：2009-07-02

    申请号：US12323073

    申请日：2008-11-25

    申请人： Natasha Kyprianou ,  Jason B. Garrison ,  Ching-Shih Chen

    发明人： Natasha Kyprianou ,  Jason B. Garrison ,  Ching-Shih Chen

    IPC分类号： A61K31/517 ,  C12N5/06

    CPC分类号： A61K31/517

    摘要： Provided is a method of inhibiting the growth of prostate cancer cells comprising administering an effective amount of DZ-50 (2-[4-biphenyl-4-sulfonyl)-piperazin-1-yl]-6,7-diisopropoxyquinazolin-4-yl-amine) to a patient in need thereof. In another aspect, a method is provided for inhibiting the initiation of prostate cancer comprising administering an effective amount of DZ-50 to a patient in need thereof. In yet another aspect, a method is provided for inhibiting the formation of a prostate tumor-derived metastatic lesion comprising administering an effective amount of DZ-50 to a patient in need thereof. In any of the aforementioned methods, a quinazoline-based drug which induces apoptosis of a prostate cancer cell may be coadministered with DZ-50. Also provided is a composition comprising DZ-50, a quinazoline-based drug which induces apoptosis of a prostate cancer cell, and a pharmaceutically acceptable carrier.

    摘要翻译： 提供了抑制前列腺癌细胞生长的方法，其包括给予有效量的DZ-50（2- [4-联苯-4-磺酰基] - 哌嗪-1-基] -6,7-二异丙氧基喹唑啉-4-基 - 胺）给有需要的患者。 另一方面，提供了一种抑制前列腺癌起始的方法，包括向有需要的患者施用有效量的DZ-50。 在另一方面，提供了一种用于抑制前列腺肿瘤衍生的转移性病变的形成的方法，包括向有需要的患者施用有效量的DZ-50。 在任何上述方法中，诱导前列腺癌细胞凋亡的基于喹唑啉的药物可以与DZ-50共同施用。 还提供了包含诱导前列腺癌细胞凋亡的基于喹唑啉的药物DZ-50和药学上可接受的载体的组合物。