公开(公告)号：US20220056534A1

公开(公告)日：2022-02-24

申请号：US17413464

申请日：2019-12-16

申请人： Natera, Inc.

发明人： Elizabeth RIVERS ,  Maxim BREVNOV, Ph.D.

IPC分类号： C12Q1/6886 ,  C12Q1/6806 ,  C12Q1/682 ,  C12Q1/6869

摘要： The invention provides methods for characterizing and analyzing circulating cells. In particular, the invention provides methods for confirming the identity of an individual cell and that the obtained sample was derived from a single cell of a defined identity. Additional methods are provided for analyzing single cell samples to determine copy number variation and aneuploidy in the context of circulating fetal cells, microdeletions, single nucleic acid variations associated with cancer, or early relapse of cancer and metastasis.