公开(公告)号：US20240115681A1

公开(公告)日：2024-04-11

申请号：US18476345

申请日：2023-09-28

申请人： National Health Research Institutes

发明人： Tsung-Hsien Chuang ,  Jing-Xing Yang ,  Jen-Chih Tseng ,  Zaida Nur Imana ,  Ming-Hsi Huang ,  Guann-Yi Yu

IPC分类号： A61K39/00 ,  A61K9/00 ,  A61K39/39 ,  A61P31/16 ,  A61P35/00

CPC分类号： A61K39/001111 ,  A61K9/0019 ,  A61K9/0043 ,  A61K39/39 ,  A61P31/16 ,  A61P35/00 ,  A61K2039/543 ,  A61K2039/55561

摘要： Provided is a pharmaceutical composition including an active pharmaceutical ingredient, a toll-like receptor (TLR) agonist, a stimulator of interferon genes (STING) agonist, and a pharmaceutically acceptable carrier. Also provided are a method for inducing immune response and a method for treating or preventing cancer or an infectious disease, including administering an effective amount of the pharmaceutical composition to a subject in need thereof.

公开(公告)号：US11898147B2

公开(公告)日：2024-02-13

申请号：US17467390

申请日：2021-09-06

申请人： National Health Research Institutes

发明人： Tsung-Hsien Chuang ,  Jen-Chih Tseng ,  Jing-Xing Yang ,  Yi-Ling Liu

IPC分类号： C07H21/02 ,  C12N15/117 ,  C07K16/28 ,  A61P35/00 ,  A61K31/711

CPC分类号： C12N15/117 ,  A61K31/711 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/2827

摘要： The present invention discloses a combinational therapy for enhancing efficacy of immune checkpoint blockade for tumors with immune suppressive microenvironment. More specifically, this combination therapy involves the treatment of cancer through immune checkpoint inhibitors and CpG-oligodeoxynucleotides.