公开(公告)号：US20220378780A1

公开(公告)日：2022-12-01

申请号：US17762878

申请日：2020-09-23

Applicant: NeOnc Technologies, Inc.

Inventor： Thomas CHEN ,  Axel SCHÖNTHAL

IPC: A61K31/495 ,  A61K31/415 ,  A61K31/4015 ,  A61K47/54 ,  A61P35/02

Abstract: The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as a primary cutaneous lymphoma which may be a cutaneous T cell lymphoma (CTCL). The CTCL may be mycosis fungoides, primary cutaneous anaplastic large cell lymphoma (ALCL), or Sezary syndrome. A patient may be administered a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene).