公开(公告)号：US20230212571A1

公开(公告)日：2023-07-06

申请号：US18001082

申请日：2021-06-08

Applicant: NeOnc Technologies, Inc.

Inventor： Thomas C. CHEN

IPC: C12N15/113 ,  A61P7/00

CPC classification number: C12N15/113 ,  A61P7/00 ,  C12N2310/141

Abstract: The disclosure relates to compositions, methods, and kits for using perillyl alcohol and/or an Argonaute protein (e.g., Ago-2) to deliver a polynucleotide to a cell. The disclosure also relates to compositions, methods, and kits for treating a condition by using perillyl alcohol and/or an Argonaute protein (e.g., Ago-2) to deliver a polynucleotide to a cell. The conditions may be brain vascular diseases and brain tumors.

公开(公告)号：US20230405125A1

公开(公告)日：2023-12-21

申请号：US18251839

申请日：2021-11-12

Applicant: NeOnc Technologies, Inc.

Inventor： Thomas C. CHEN

IPC: A61K47/10 ,  A61P35/00 ,  A61K45/06

CPC classification number: A61K47/10 ,  A61P35/00 ,  A61K45/06

Abstract: The present invention provides an intranasal glioblastoma therapy with purified perillyl alcohol. Patients with recurrent glioblastoma when treated with perillyl alcohol purified by the disclosed methods showed improved survival when compared to historical controls. Glioblastoma patients with an isocitrate dehydrogenase 1 (IDH1)-mutation showed improved survival when compared with wild-type IDH patients.