公开(公告)号：US20190048346A1

公开(公告)日：2019-02-14

申请号：US16169606

申请日：2018-10-24

Applicant: NeOnc Technologies, Inc.

Inventor： Florence M. Hofman ,  Raquel M.S. Ferreira ,  Steven L. Giannotta ,  Thomas C. Chen

IPC: C12N15/113 ,  A61K45/06 ,  C12N15/11 ,  A61K31/713 ,  A61K38/46

Abstract: The invention relates to compositions, methods and kits for using Argonaute-2 (Ago-2) as a systemic carrier to deliver a miRNA to an endothelial cell. The invention also relates to compositions, methods and kits for inhibiting angiogenesis and/or treating a condition by using Ago-2 as a systemic carrier to deliver a miRNA to an endothelial cell. The condition includes but is not limited to brain vascular diseases and brain tumors.