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    Methods of treating diseases with a VEGF antagonist
    1.
    发明授权
    Methods of treating diseases with a VEGF antagonist 有权
    用VEGF拮抗剂治疗疾病的方法

    公开(公告)号：US07531172B2

    公开(公告)日：2009-05-12

    申请号：US11502736

    申请日：2006-08-11

    申请人： Neil Stahl ,  George D. Yancopoulos ,  Eric Furfine ,  Jesse M. Cedarbaum

    发明人： Neil Stahl ,  George D. Yancopoulos ,  Eric Furfine ,  Jesse M. Cedarbaum

    IPC分类号： A61K38/18 ,  C07K14/71 ,  C12N15/62

    CPC分类号： A61K38/179

    摘要： A method of reducing or preventing hypertension associated with administration of a vascular endothelial growth factor (VEGF) antagonist in a human subjects suffering from a disease or condition treatable with a VEGF antagonist in which is it desirable to reduce or prevent hypertension. The method is particularly useful for treatment of patients unresponsive to treatment with a VEGF inhibitor administered intravenously.

    摘要翻译： 在患有可用VEGF拮抗剂治疗的疾病或病症的人类受试者中降低或预防与血管内皮生长因子（VEGF）拮抗剂的给药相关的高血压的方法，其中希望减少或预防高血压。 该方法对于治疗对用静脉内施用的VEGF抑制剂治疗无反应的患者特别有用。

    Method of administering and using VEGF inhibitors for the treatment of non small cell lung cancer
    5.
    发明授权
    Method of administering and using VEGF inhibitors for the treatment of non small cell lung cancer 有权
    VEGF和VEGF抑制剂治疗非小细胞肺癌的方法

    公开(公告)号：US07482001B2

    公开(公告)日：2009-01-27

    申请号：US12072965

    申请日：2008-02-29

    申请人： Jesse M. Cedarbaum

    发明人： Jesse M. Cedarbaum

    IPC分类号： A61K38/18 ,  C07K14/71 ,  C12N15/62

    CPC分类号： C07K14/71 ,  A61K38/00 ,  A61K38/17 ,  A61K45/06 ,  C07K2319/30 ,  A61K2300/00

    摘要： A method of treating a human patient suffering from cancer, comprising administering an effective amount of a vascular endothelial growth factor (VEGF) trap antagonist to the human patient, the method comprising: (a) administering to the patient an initial dose of at least approximately 0.3 mg/kg of the VEGF antagonist; and (b) administering to the patient a plurality of subsequent doses of the VEGF antagonist in an amount that is approximately the same or less of the initial dose, wherein the subsequent doses are separated in time from each other by at least one day. The methods of the invention are useful for treating a human cancer selected from the group consisting of renal cell carcinoma, pancreatic carcinoma, breast cancer, prostate cancer, colorectal cancer, malignant mesothelioma, multiple myeloma, ovarian cancer, and melanoma. The invention is further useful for treating a condition which benefits from the reduction of VEGFA and placental growth factor (PLGF).

    摘要翻译： 一种治疗患有癌症的人类患者的方法，包括向人类患者施用有效量的血管内皮生长因子（VEGF）捕获拮抗剂，所述方法包括：（a）向患者施用至少约为 0.3mg / kg的VEGF拮抗剂; 和（b）向患者施用多个后续剂量的VEGF拮抗剂，其量为初始剂量大致相同或更小，其中随后的剂量在时间上彼此分开至少一天。 本发明的方法可用于治疗选自肾细胞癌，胰腺癌，乳腺癌，前列腺癌，结肠直肠癌，恶性间皮瘤，多发性骨髓瘤，卵巢癌和黑素瘤的人类癌症。 本发明可用于治疗从减少VEGFA和胎盘生长因子（PLGF）中获益的病症。

    Method of administering and using VEGF inhibitors for the treatment of colorectal cancer
    6.
    发明授权
    Method of administering and using VEGF inhibitors for the treatment of colorectal cancer 有权
    给予和使用VEGF抑制剂治疗结肠直肠癌的方法

    公开(公告)号：US07479275B2

    公开(公告)日：2009-01-20

    申请号：US12074140

    申请日：2008-02-29

    申请人： Jesse M. Cedarbaum

    发明人： Jesse M. Cedarbaum

    IPC分类号： A61K38/18 ,  C07K14/71 ,  C12N15/62

    CPC分类号： C07K14/71 ,  A61K38/00 ,  A61K38/17 ,  A61K45/06 ,  C07K2319/30 ,  A61K2300/00

    摘要： A method of treating a human patient suffering from cancer, comprising administering an effective amount of a vascular endothelial growth factor (VEGF) trap antagonist to the human patient, the method comprising: (a) administering to the patient an initial dose of at least approximately 0.3 mg/kg of the VEGF antagonist; and (b) administering to the patient a plurality of subsequent doses of the VEGF antagonist in an amount that is approximately the same or less of the initial dose, wherein the subsequent doses are separated in time from each other by at least one day. The methods of the invention are useful for treating a human cancer selected from the group consisting of renal cell carcinoma, pancreatic carcinoma, breast cancer, prostate cancer, colorectal cancer, malignant mesothelioma, multiple myeloma, ovarian cancer, and melanoma. The invention is further useful for treating a condition which benefits from the reduction of VEGFA and placental growth factor (PLGF).

    摘要翻译： 一种治疗患有癌症的人类患者的方法，包括向人类患者施用有效量的血管内皮生长因子（VEGF）捕获拮抗剂，所述方法包括：（a）向患者施用至少约为 0.3mg / kg的VEGF拮抗剂; 和（b）向患者施用多个后续剂量的VEGF拮抗剂，其量为初始剂量大致相同或更小，其中随后的剂量在时间上彼此分开至少一天。 本发明的方法可用于治疗选自肾细胞癌，胰腺癌，乳腺癌，前列腺癌，结肠直肠癌，恶性间皮瘤，多发性骨髓瘤，卵巢癌和黑素瘤的人类癌症。 本发明可用于治疗从减少VEGFA和胎盘生长因子（PLGF）中获益的病症。

    Method of administering and using VEGF inhibitors for the treatment of human cancer
    7.
    发明申请
    Method of administering and using VEGF inhibitors for the treatment of human cancer 有权

    公开(公告)号：US20080188419A1

    公开(公告)日：2008-08-07

    申请号：US12074096

    申请日：2008-02-29

    申请人： Jesse M. Cedarbaum

    发明人： Jesse M. Cedarbaum

    IPC分类号： A61K38/16 ,  A61P35/00

    CPC分类号： C07K14/71 ,  A61K38/00 ,  A61K38/17 ,  A61K45/06 ,  C07K2319/30 ,  A61K2300/00

    摘要： A method of treating a human patient suffering from cancer, comprising administering an effective amount of a vascular endothelial growth factor (VEGF) trap antagonist to the human patient, the method comprising: (a) administering to the patient an initial dose of at least approximately 0.3 mg/kg of the VEGF antagonist; and (b) administering to the patient a plurality of subsequent doses of the VEGF antagonist in an amount that is approximately the same or less of the initial dose, wherein the subsequent doses are separated in time from each other by at least one day. The methods of the invention are useful for treating a human cancer selected from the group consisting of renal cell carcinoma, pancreatic carcinoma, breast cancer, prostate cancer, colorectal cancer, malignant mesothelioma, multiple myeloma, ovarian cancer, and melanoma. The invention is further useful for treating a condition which benefits from the reduction of VEGFA and placental growth factor (PLGF).

    Method of administering and using VEGF inhibitors for the treatment of human cancer
    8.
    发明申请
    Method of administering and using VEGF inhibitors for the treatment of human cancer 有权

    公开(公告)号：US20080188418A1

    公开(公告)日：2008-08-07

    申请号：US12072966

    申请日：2008-02-29

    申请人： Jesse M. Cedarbaum

    发明人： Jesse M. Cedarbaum

    IPC分类号： A61K38/16 ,  A61P35/00

    CPC分类号： C07K14/71 ,  A61K38/00 ,  A61K38/17 ,  A61K45/06 ,  C07K2319/30 ,  A61K2300/00

    摘要： A method of treating a human patient suffering from cancer, comprising administering an effective amount of a vascular endothelial growth factor (VEGF) trap antagonist to the human patient, the method comprising: (a) administering to the patient an initial dose of at least approximately 0.3 mg/kg of the VEGF antagonist; and (b) administering to the patient a plurality of subsequent doses of the VEGF antagonist in an amount that is approximately the same or less of the initial dose, wherein the subsequent doses are separated in time from each other by at least one day. The methods of the invention are useful for treating a human cancer selected from the group consisting of renal cell carcinoma, pancreatic carcinoma, breast cancer, prostate cancer, colorectal cancer, malignant mesothelioma, multiple myeloma, ovarian cancer, and melanoma. The invention is further useful for treating a condition which benefits from the reduction of VEGFA and placental growth factor (PLGF).

    Method of administering and using VEGF inhibitors for the treatment of human cancer
    9.
    发明申请
    Method of administering and using VEGF inhibitors for the treatment of human cancer 有权

    公开(公告)号：US20080171703A1

    公开(公告)日：2008-07-17

    申请号：US12072965

    申请日：2008-02-29

    申请人： Jesse M. Cedarbaum

    发明人： Jesse M. Cedarbaum

    IPC分类号： A61K38/17 ,  A61P35/00

    CPC分类号： C07K14/71 ,  A61K38/00 ,  A61K38/17 ,  A61K45/06 ,  C07K2319/30 ,  A61K2300/00

    摘要： A method of treating a human patient suffering from cancer, comprising administering an effective amount of a vascular endothelial growth factor (VEGF) trap antagonist to the human patient, the method comprising: (a) administering to the patient an initial dose of at least approximately 0.3 mg/kg of the VEGF antagonist; and (b) administering to the patient a plurality of subsequent doses of the VEGF antagonist in an amount that is approximately the same or less of the initial dose, wherein the subsequent doses are separated in time from each other by at least one day. The methods of the invention are useful for treating a human cancer selected from the group consisting of renal cell carcinoma, pancreatic carcinoma, breast cancer, prostate cancer, colorectal cancer, malignant mesothelioma, multiple myeloma, ovarian cancer, and melanoma. The invention is further useful for treating a condition which benefits from the reduction of VEGFA and placental growth factor (PLGF).

    Method of administering and using VEGF inhibitors for the treatment of prostate cancer
    10.
    发明授权
    Method of administering and using VEGF inhibitors for the treatment of prostate cancer 有权
    给予和使用VEGF抑制剂治疗前列腺癌的方法

    公开(公告)号：US07482002B2

    公开(公告)日：2009-01-27

    申请号：US12072966

    申请日：2008-02-29

    申请人： Jesse M. Cedarbaum

    发明人： Jesse M. Cedarbaum

    IPC分类号： A61K38/18 ,  C07K14/71 ,  C12N15/62

    CPC分类号： C07K14/71 ,  A61K38/00 ,  A61K38/17 ,  A61K45/06 ,  C07K2319/30 ,  A61K2300/00

    摘要： A method of treating a human patient suffering from cancer, comprising administering an effective amount of a vascular endothelial growth factor (VEGF) trap antagonist to the human patient, the method comprising: (a) administering to the patient an initial dose of at least approximately 0.3 mg/kg of the VEGF antagonist; and (b) administering to the patient a plurality of subsequent doses of the VEGF antagonist in an amount that is approximately the same or less of the initial dose, wherein the subsequent doses are separated in time from each other by at least one day. The methods of the invention are useful for treating a human cancer selected from the group consisting of renal cell carcinoma, pancreatic carcinoma, breast cancer, prostate cancer, colorectal cancer, malignant mesothelioma, multiple myeloma, ovarian cancer, and melanoma. The invention is further useful for treating a condition which benefits from the reduction of VEGFA and placental growth factor (PLGF).

    摘要翻译： 一种治疗患有癌症的人类患者的方法，包括向人类患者施用有效量的血管内皮生长因子（VEGF）捕获拮抗剂，所述方法包括：（a）向患者施用至少约为 0.3mg / kg的VEGF拮抗剂; 和（b）向患者施用多个后续剂量的VEGF拮抗剂，其量为初始剂量大致相同或更小，其中随后的剂量在时间上彼此分开至少一天。 本发明的方法可用于治疗选自肾细胞癌，胰腺癌，乳腺癌，前列腺癌，结肠直肠癌，恶性间皮瘤，多发性骨髓瘤，卵巢癌和黑素瘤的人类癌症。 本发明可用于治疗从减少VEGFA和胎盘生长因子（PLGF）中获益的病症。