公开(公告)号：US20230158164A1

公开(公告)日：2023-05-25

申请号：US17601611

申请日：2020-04-04

申请人： Nektar Therapeutics ,  Fred Hutchinson Cancer Research Center

发明人： Antonio Mario Querido Marcondes ,  Peter Benedict Kirk ,  Takahiro Miyazaki ,  Cameron J. Turtle ,  Stanley R. Riddell ,  Cassie K. Chou ,  Simon P. Fräßle

IPC分类号： A61K47/64 ,  A61K35/17 ,  C07K16/28 ,  A61P35/00 ,  A61K9/00 ,  A61K38/17

CPC分类号： A61K47/642 ,  A61K35/17 ,  C07K16/2803 ,  A61P35/00 ,  A61K9/0019 ,  A61K38/1774 ,  C07K2317/24

摘要： Provided are methods and compositions directed to the treatment of an individual having cancer by (i) administering to the individual an adoptive cellular immunotherapy composition comprising CAR T cells and (ii) administering to the individual an interleukin-15 receptor agonist, such as, for example, a long-acting interleukin-15 receptor agonist.