公开(公告)号：US20240425483A1

公开(公告)日：2024-12-26

申请号：US18712285

申请日：2022-11-28

Applicant: NeoPhore Limited

Inventor： Julian Blagg ,  Martin Drysdale ,  David Clark

IPC: C07D401/14 ,  A61K31/497 ,  A61P35/00 ,  C07D417/14

Abstract: The present invention relates to compounds of Formula (I) that target PMS2, a component of DNA Mismatch Repair (MMR): wherein R2, R4, R6, A1, A2, A4, L and Q are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PMS2 is implicated.

公开(公告)号：US20230183197A1

公开(公告)日：2023-06-15

申请号：US17925493

申请日：2020-06-01

Applicant: NeoPhore Limited

Inventor： Julian Blagg ,  Jon Roffey ,  Martin Drysdale ,  Paul Winship ,  David Clark

IPC: C07D295/16 ,  C07D239/26 ,  C07D209/44 ,  C07D207/12 ,  C07D211/42 ,  C07D213/16 ,  C07D471/04 ,  C07D231/12 ,  C07D249/04 ,  C07D401/12 ,  C07D217/04 ,  C07D217/16 ,  C07D265/36 ,  C07D209/08 ,  C07D215/08 ,  C07D405/12 ,  C07D401/04 ,  C07D403/12 ,  C07D403/04 ,  A61K45/06

CPC classification number: C07D295/16 ,  C07D239/26 ,  C07D209/44 ,  C07D207/12 ,  C07D211/42 ,  C07D213/16 ,  C07D471/04 ,  C07D231/12 ,  C07D249/04 ,  C07D401/12 ,  C07D217/04 ,  C07D217/16 ,  C07D265/36 ,  C07D209/08 ,  C07D215/08 ,  C07D405/12 ,  C07D401/04 ,  C07D403/12 ,  C07D403/04 ,  A61K45/06

Abstract: The present invention relates to compounds of Formula (I) that target the MLH1 and/or PMS2 proteins that are components of the DNA Mismatch Repair (MMR) process:




wherein R1, R2, R3, R4, R6 and R10 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which MLH1 and/or PMS2 activity is implicated.

公开(公告)号：US20240425453A1

公开(公告)日：2024-12-26

申请号：US18712311

申请日：2022-11-28

Applicant: NeoPhore Limited

Inventor： Julian Blagg ,  Martin Drysdale ,  David Clark ,  Paul Winship

IPC: C07D209/44 ,  A61K31/4035 ,  A61K31/47 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06 ,  C07D217/20 ,  C07D403/12

Abstract: The present invention relates to compounds of Formula (II) that target the PMS2 proteins that are components of the DNA Mismatch Repair (MMR) process: wherein R2, R4, R6, Y1, Y2, A1, A2, A3, and A4 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PMS2 activity is implicated.

公开(公告)号：US20240293392A1

公开(公告)日：2024-09-05

申请号：US18570244

申请日：2022-07-18

Applicant: NeoPhore Limited

Inventor： Julian Blagg ,  Martin Drysdale ,  David Clark ,  Paul Winship

IPC: A61K31/4725 ,  A61K31/4035 ,  A61K31/4375 ,  A61K31/496 ,  A61K31/501 ,  C07D209/44 ,  C07D217/06 ,  C07D401/12 ,  C07D405/14 ,  C07D471/04

CPC classification number: A61K31/4725 ,  A61K31/4035 ,  A61K31/4375 ,  A61K31/496 ,  A61K31/501 ,  C07D209/44 ,  C07D217/06 ,  C07D401/12 ,  C07D405/14 ,  C07D471/04

Abstract: The present invention relates to compounds of Formula (I) that target the MLH1 or MLH1 and PMS2 proteins that are components of the DNA Mismatch Repair (MMR) process: Formula (I) wherein R6, Y1, Y2, A1, A2, A3, A4, R11, R12, R13 and R14 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which MLH1 or MLH1 and PMS2 activity is implicated.