公开(公告)号：US20230061002A1

公开(公告)日：2023-03-02

申请号：US17793912

申请日：2021-01-20

申请人： NeoPhore Limited

发明人： Julian Blagg ,  Jonathon Richard Anthony Roffey ,  Paul Colin Michael Winship ,  Gareth William Langley

IPC分类号： G01N33/573 ,  C07D209/44 ,  G01N33/68

摘要： The present invention relates to novel probe compounds of formulae I and II defined herein. The present invention also relates to methods of synthesising these novel probe compounds and to their use in assays and screens for determining the binding of a test molecule to the ATP-binding site of a target protein, such as, for example, the Mismatch Repair (MMR) component proteins PMS2 and MLH1, or for determining the location and/or quantity of such target proteins in a biological sample.