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公开(公告)号:US11491158B2
公开(公告)日:2022-11-08
申请号:US17140471
申请日:2021-01-04
发明人: Simona Bindi , Davide Carenzi , Ilaria Motto , Maurizio Pulici
IPC分类号: A61K31/519 , C07D487/04 , C07D513/04 , A61P37/00 , A61P25/28 , A61P35/00 , A61K31/4355 , A61K31/4365 , C07D491/048 , C07D495/04
摘要: The invention relates to N-(substituted-phenyl)-sulfonamide compounds, which are extremely useful as inhibitors of protein kinases (e.g. PERK kinase) and accordingly can be used for the treatment of cell proliferative disorders, such as cancer, or diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.
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公开(公告)号:US20190201406A1
公开(公告)日:2019-07-04
申请号:US16312061
申请日:2017-06-19
发明人: Simona Bindi , Davide Carenzi , Ilaria Motto , Maurizio Pulici
IPC分类号: A61K31/519 , A61P37/00 , A61P25/28 , A61P35/00 , A61K31/4355 , A61K31/4365 , C07D487/04 , C07D491/048 , C07D495/04
摘要: The invention relates to N-(substituted-phenyl)-sulfonamide compounds, which are extremely useful as inhibitors of protein kinases (e.g. PERK kinase) and accordingly can be used for the treatment of cell proliferative disorders, such as cancer, or diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.
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公开(公告)号:US20180339978A1
公开(公告)日:2018-11-29
申请号:US16055396
申请日:2018-08-06
发明人: Maria Gabriella Brasca , Simona Bindi , Marina Caldarelli , Marcella Nesi , Sten Christian Orrenius , Achille Panzeri
IPC分类号: C07D403/04 , C07F7/08 , C07F5/04 , C07D487/04 , C07D473/00 , A61K31/506 , A61K45/06 , A61K31/53 , A61K31/52 , A61K31/519 , C07D401/04
摘要: The present invention relates to substituted pyrrole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular Jak family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.
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公开(公告)号:US10561660B2
公开(公告)日:2020-02-18
申请号:US16312061
申请日:2017-06-19
发明人: Simona Bindi , Davide Carenzi , Ilaria Motto , Maurizio Pulici
IPC分类号: C07D487/04 , A61K31/519 , C07D513/04 , A61P37/00 , A61P25/28 , A61P35/00 , A61K31/4355 , A61K31/4365 , C07D491/048 , C07D495/04
摘要: The invention relates to N-(substituted-phenyl)-sulfonamide compounds, which are extremely useful as inhibitors of protein kinases (e.g. PERK kinase) and accordingly can be used for the treatment of cell proliferative disorders, such as cancer, or diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.
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公开(公告)号:US20170253578A1
公开(公告)日:2017-09-07
申请号:US15598976
申请日:2017-05-18
发明人: Maria Gabriella Brasca , Simona Bindi , Marina Caldarelli , Marcella Nesi , Sten Christian Orrenius , Achille Panzeri
IPC分类号: C07D403/04 , C07D473/00 , C07D487/04 , A61K45/06 , A61K31/53 , A61K31/52 , A61K31/519 , A61K31/506 , C07F5/04 , C07D401/04 , C07F7/08
CPC分类号: C07D403/04 , A61K31/506 , A61K31/519 , A61K31/52 , A61K31/53 , A61K45/06 , C07D401/04 , C07D473/00 , C07D487/04 , C07F5/04 , C07F7/083
摘要: The present invention relates to substituted pyrrole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular Jak family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.
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公开(公告)号:US10918642B2
公开(公告)日:2021-02-16
申请号:US16721267
申请日:2019-12-19
发明人: Simona Bindi , Davide Carenzi , Ilaria Motto , Maurizio Pulici
IPC分类号: C07D487/04 , A61K31/519 , C07D513/04 , A61P37/00 , A61P25/28 , A61P35/00 , A61K31/4355 , A61K31/4365 , C07D491/048 , C07D495/04
摘要: The invention relates to N-(substituted-phenyl)-sulfonamide compounds, which are extremely useful as inhibitors of protein kinases (e.g. PERK kinase) and accordingly can be used for the treatment of cell proliferative disorders, such as cancer, or diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.
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公开(公告)号:US10071986B2
公开(公告)日:2018-09-11
申请号:US15598976
申请日:2017-05-18
发明人: Maria Gabriella Brasca , Simona Bindi , Marina Caldarelli , Marcella Nesi , Sten Christian Orrenius , Achille Panzeri
IPC分类号: C07D471/04 , C07D487/04 , C07D401/04 , C07D403/04 , C07D473/00 , A61K45/06 , A61K31/52 , A61K31/519 , A61K31/506 , C07F5/04 , A61K31/53 , C07F7/08
CPC分类号: C07D403/04 , A61K31/506 , A61K31/519 , A61K31/52 , A61K31/53 , A61K45/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/00 , A61P37/06 , C07D401/04 , C07D471/04 , C07D473/00 , C07D487/04 , C07F5/04 , C07F7/083
摘要: The present invention relates to substituted pyrrole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular Jak family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.
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公开(公告)号:US20150166512A1
公开(公告)日:2015-06-18
申请号:US14418555
申请日:2013-07-24
发明人: Maria Gabriella Brasca , Simona Bindi , Marina Caldarelli , Marcella Nesi , Sten Christian Orrenius , Achille Panzeri
IPC分类号: C07D403/04 , C07F5/04 , C07F7/08 , A61K45/06 , A61K31/519 , C07D473/00 , A61K31/52 , A61K31/53 , A61K31/506 , C07D487/04
CPC分类号: C07D403/04 , A61K31/506 , A61K31/519 , A61K31/52 , A61K31/53 , A61K45/06 , C07D401/04 , C07D473/00 , C07D487/04 , C07F5/04 , C07F7/083
摘要: The present invention relates to substituted pyrrole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular Jak family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.
摘要翻译: 本发明涉及调节蛋白激酶活性的取代吡咯化合物,因此可用于治疗由失调的蛋白激酶活性引起的疾病,特别是Jak家族激酶。 本发明还提供了制备这些化合物的方法,包含这些化合物的药物组合物,以及使用这些化合物治疗疾病的方法或含有它们的药物组合物。
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公开(公告)号:US20210128563A1
公开(公告)日:2021-05-06
申请号:US17140471
申请日:2021-01-04
发明人: Simona Bindi , Davide Carenzi , Ilaria Motto , Maurizio Pulici
IPC分类号: A61K31/519 , C07D487/04 , C07D513/04 , A61P37/00 , A61P25/28 , A61P35/00 , A61K31/4355 , A61K31/4365 , C07D491/048 , C07D495/04
摘要: The invention relates to N-(substituted-phenyl)-sulfonamide compounds, which are extremely useful as inhibitors of protein kinases (e.g. PERK kinase) and accordingly can be used for the treatment of cell proliferative disorders, such as cancer, or diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.
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公开(公告)号:US10479779B2
公开(公告)日:2019-11-19
申请号:US16055396
申请日:2018-08-06
发明人: Maria Gabriella Brasca , Simona Bindi , Marina Caldarelli , Marcella Nesi , Sten Christian Orrenius , Achille Panzeri
IPC分类号: C07D403/04 , C07D401/04 , C07D473/00 , C07D487/04 , C07D471/04 , A61P35/02 , A61P29/00 , A61P35/04 , A61P37/00 , A61P35/00 , A61P19/02 , A61P37/06 , A61K31/506 , A61K31/519 , A61K31/52 , A61K31/53 , A61K45/06 , C07F5/04 , C07F7/08
摘要: The present invention relates to substituted pyrrole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular Jak family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.
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