INTRON FRAGMENTS
    2.
    发明申请

    公开(公告)号:US20220010332A1

    公开(公告)日:2022-01-13

    申请号:US17365884

    申请日:2021-07-01

    Abstract: Novel intron fragments are provided. The intron fragments can increase gene expression to levels equal to or higher than those achieved by the full-length intron while maintaining their ability to increase gene expression even when combined with various types of promoters and splicing donors. Particularly, the intron fragments enable loading of larger transgenes when used in genetic information delivery systems whose size is limited, for example, adeno-associated viruses (AAVs) and rhabdoviruses. Therefore, the use of the intron fragments is expected to extend the range of therapeutic genes.

    INTRON FRAGMENTS
    3.
    发明申请

    公开(公告)号:US20250163455A1

    公开(公告)日:2025-05-22

    申请号:US18945052

    申请日:2024-11-12

    Abstract: Novel intron fragments are provided. The intron fragments can increase gene expression to levels equal to or higher than those achieved by the full-length intron while maintaining their ability to increase gene expression even when combined with various types of promoters and splicing donors. Particularly, the intron fragments enable loading of larger transgenes when used in genetic information delivery systems whose size is limited, for example, adeno-associated viruses (AAVs) and rhabdoviruses. Therefore, the use of the intron fragments is expected to extend the range of therapeutic genes.

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