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公开(公告)号:US20210363119A1
公开(公告)日:2021-11-25
申请号:US17052580
申请日:2019-05-02
IPC分类号: C07D305/12
摘要: The disclosure provides proteasome inhibitors that can be used to halt cell division of rapidly dividing cells by preventing the degradation of cell cycle-regulating proteins, such as cyclins, cyclin-dependent kinase inhibitors, and p53. The proteasome inhibitor compounds can be used to inhibit the proliferation of cancer cells.