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公开(公告)号：US20220185896A1
公开(公告)日：2022-06-16
申请号：US17607878
申请日：2020-05-01
发明人： Shohei KOIDE , George MILLER , Akiko KOIDE , Linxiao CHEN , Aleksandra FILIPOVIC , Eric ELENKO , Joseph BOLEN
摘要： Disclosed herein are methods for treating solid tumors (e.g., pancreatic adenocarcinoma (PDA), colorectal cancer (CRC), hepatocellular carcinoma (HCC)), or Cholangiocarcinoma and others), including, but not limited to, metastatic tumors, using an anti-Galectin-9 antibody.
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公开(公告)号：US20220204629A1
公开(公告)日：2022-06-30
申请号：US17598215
申请日：2020-03-25
发明人： Shohei KOIDE , George MILLER , Akiko KOIDE , Linxiao CHEN , Aleksandra FILIPOVIC , Eric ELENKO , Joseph BOLEN
IPC分类号： C07K16/28 , A61K39/395 , A61K31/7068 , A61K31/337 , A61P35/00
摘要： Disclosed herein are anti-Galectin-9 antibodies and methods of using in modulating (e.g., increasing) immune responses in a subject, either taken alone or in combination with an immune checkpoint inhibitor, such as a PD-1 inhibitor.
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公开(公告)号：US20220073612A1
公开(公告)日：2022-03-10
申请号：US17424474
申请日：2020-01-23
发明人： Shohei KOIDE , George MILLER , Akiko KOIDE , Tatyana PANCHENKO , Takamitsu HATTORI , Aleksandra FILIPOVIC , Eric ELENKO , Joseph BOLEN
摘要： Disclosed herein are antibodies specific to a delta-1 chain of a γδ T cell receptor and methods of using such for modulating γδ T cell bioactivity. Such anti-Delta 1 antibodies may also be used to treat diseases associated with γδ T cell activation, such as solid tumors, or for detecting presence of γδ1 T cells.
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公开(公告)号：US20240109968A1
公开(公告)日：2024-04-04
申请号：US18253756
申请日：2021-11-19
发明人： Shohei KOIDE , Akiko KOIDE , Aleksandra FILIPOVIC , Eric ELENKO , Joseph BOLEN
CPC分类号： C07K16/2851 , A61K9/0019 , A61P35/00 , C07K16/2818 , A61K2039/507
摘要： Disclosed herein are methods for treating solid tumors (e.g., pancreatic adenocarcinoma (PDA), colorectal cancer (CRC), hepatocellular carcinoma (HCC)), or Cholangiocarcinoma and others), including, but not limited to, metastatic tumors, using an anti-Galectin-9 antibody.
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公开(公告)号：US20240043543A1
公开(公告)日：2024-02-08
申请号：US18253754
申请日：2021-11-19
发明人： Shohei KOIDE , Akiko KOIDE , Aleksandra FILIPOVIC , Eric ELENKO , Joseph BOLEN
CPC分类号： C07K16/2851 , A61P35/04 , C07K2317/565 , A61K2039/545
摘要： Combined therapy for a solid tumor, comprising an antibody that binds human galectin-9 (anti-Gal9 antibody, e.g., G9.2-17), and one or more chemotherapeutics, for example, gemcitabine, paclitaxel, or a combination thereof.
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公开(公告)号：US20220332832A1
公开(公告)日：2022-10-20
申请号：US17631378
申请日：2020-08-03
发明人： Shohei KOIDE , George MILLER , Akiko KOIDE , Linxiao CHEN , Aleksandra FILIPOVIC , Eric ELENKO , Joseph BOLEN
摘要： Combined therapy for a solid tumor, comprising an antibody that binds human galectin-9 (anti-Gal9 antibody, e.g, G9.2-17), and one or more chemotherapeutics, for example, gemcitabine, paclitaxel, or a combination thereof.
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公开(公告)号：US20220178930A1
公开(公告)日：2022-06-09
申请号：US17607879
申请日：2020-05-01
发明人： Shohei KOIDE , George MILLER , Akiko KOIDE , Linxiao CHEN , Aleksandra FILIPOVIC , Eric ELENKO , Joseph BOLEN
IPC分类号： G01N33/574 , C07K16/28
摘要： Disclosed herein are methods for identifying a subject as having certain solid cancers such as breast cancer, colorectal colon cancer, or non-small cell lung cancer, or being at risk for the cancer based on the level of Galectin-9 in a biological sample (e.g., a blood sample) from a subject suspected of having the solid cancer.
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公开(公告)号：US20240287195A1
公开(公告)日：2024-08-29
申请号：US18250165
申请日：2021-10-26
申请人： PURETECH LYT, INC.
发明人： Aleksandra FILIPOVIC , Joseph BOLEN , Eric ELENKO
IPC分类号： C07K16/28 , A61K39/00 , A61P35/04 , G01N33/574
CPC分类号： C07K16/2851 , A61P35/04 , C07K16/2818 , G01N33/57407 , G01N33/57492 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K2317/55 , C07K2317/732 , G01N2333/4724
摘要： Methods for treating an ocular melanoma in a patient. e.g., uveal melanoma, comprising administering to the patient an effective amount of an antibody that binds galectin-9). Also provided herein are methods for identifying a subject as having the ocular melanoma based on the level of Galectin-9) in a biological sample (e.g., a blood sample) from a subject suspected of having the ocular melanoma.
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9.发明公开公开(公告)号：US20240182583A1
公开(公告)日：2024-06-06
申请号：US18556394
申请日：2022-04-29
申请人： PURETECH LYT, INC.
IPC分类号： C07K16/28 , A61K9/00 , A61K31/337 , A61K31/7068 , A61K39/00 , A61P35/00
CPC分类号： C07K16/2851 , A61K9/0019 , A61K31/337 , A61K31/7068 , A61P35/00 , A61K2039/505 , A61K2039/54 , A61K2039/545 , A61K2039/55
摘要： Disclosed herein are combined therapies for treating solid tumors (e.g., pancreatic ductal adenocarcinoma (PDAC), colorectal cancer (CRC), hepatocellular carcinoma (HCC), cholangiocarcinoma (CAA), renal cell carcinoma (RCC), urothelial, head and neck, breast cancer, lung cancer, or other gastrointestinal solid tumors), comprising an antibody that binds human galectin-9 (anti-Gal9) antibody, e.g., G9.2-17), and one or more chemotherapeutics, for example, gemcitabine, paclitaxel, or a combination thereof.
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公开(公告)号：US20240190970A1
公开(公告)日：2024-06-13
申请号：US18556387
申请日：2022-04-29
申请人： PURETECH LYT, INC.
CPC分类号： C07K16/2851 , A61P35/00 , C07K16/2818 , A61K2039/505 , A61K2039/545 , C07K2317/92
摘要： Disclosed herein are methods for treating solid tumors (e.g., pancreatic ductal adenocarcinoma (PDAC), colorectal cancer (CRC), hepatocellular carcinoma (HCC), cholangiocarcinoma (CAA), renal cell carcinoma (RCC), urothelial, head and neck, breast cancer, lung cancer, or other gastrointestinal solid tumors), using an anti-Galectin-9) antibody, e.g., as a monotherapy or as a combined therapy with an immune checkpoint inhibitor.
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