公开(公告)号：US20090117169A1

公开(公告)日：2009-05-07

申请号：US12150176

申请日：2008-04-25

申请人： Nicholas E.S. Sibinga ,  Rong Hou

发明人： Nicholas E.S. Sibinga ,  Rong Hou

IPC分类号： A61K9/00 ,  C07K14/705 ,  C12N15/63

CPC分类号： C07K14/705 ,  A61F2/82 ,  A61F2250/0067 ,  A61K38/00

摘要： Provided is an extracellular domain of a mammalian Fat1 (Fat1EC). Also provided is an intracellular domain of a mammalian Fat1 (Fat1IC). Additionally provided is a vector comprising a nucleic acid sequence encoding the Fat1EC. A vector comprising a nucleic acid sequence encoding the Fat1IC is further provided. Also, a vascular stent coated with the Fat1EC is provided. Further provided is a vascular stent coated with a Fat1 ligand that activates Fat1. A method of treating a patient at risk for restenosis of a blood vessel is additionally provided. Further, methods of treating an injured blood vessel in a patient is provided. A method of treating a patient at risk for restenosis of a blood vessel or having an injured blood vessel is also provided.

摘要翻译： 提供哺乳动物Fat1（Fat1EC）的细胞外结构域。 还提供了哺乳动物Fat1（Fat1IC）的细胞内结构域。 另外提供了包含编码Fat1EC的核酸序列的载体。 还提供了包含编码Fat1IC的核酸序列的载体。 此外，还提供了涂有Fat1EC的血管支架。 还提供涂覆有活化Fat1的Fat1配体的血管支架。 另外提供了治疗存在血管再狭窄风险的患者的方法。 此外，提供了治疗患者的受伤血管的方法。 还提供了治疗有血管再狭窄或具有受伤血管风险的患者的方法。