公开(公告)号：US20230414621A1

公开(公告)日：2023-12-28

申请号：US18251283

申请日：2021-10-28

Applicant: Nicox S.A.

Inventor： Tomas NAVRATIL ,  Francesco IMPAGNATIELLO ,  Nicoletta ALMIRANTE

IPC: A61K31/519 ,  A61K31/506

CPC classification number: A61K31/519 ,  A61K31/506

Abstract: The invention relates to the use of nitric oxide releasing cyclic guanosine 3′,5′ monophosphate (cGMP) phosphodiesterase type 5 inhibitors (NO-PDES inhibitors) in a method for the treatment of dry age-related macular degeneration and geographic atrophy. This invention also relates to the use of such compounds to provide neuroprotection to the eye in a patient suffering from glaucoma or retinal neuropathies.