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39 条记录 (耗时 0.035 秒)

    Inotropic and diuretic effects of GLP-1 and GLP-1 agonists
    3.
    发明申请
    Inotropic and diuretic effects of GLP-1 and GLP-1 agonists 失效
    GLP-1和GLP-1激动剂的变力和利尿作用

    公开(公告)号：US20050037958A1

    公开(公告)日：2005-02-17

    申请号：US10656093

    申请日：2003-09-05

    申请人： Andrew Young ,  Will Vine ,  Nigel Beeley ,  Kathryn Prickett

    发明人： Andrew Young ,  Will Vine ,  Nigel Beeley ,  Kathryn Prickett

    IPC分类号： A61K31/00 ,  A61K38/22 ,  A61K38/26

    CPC分类号： A61K38/26 ,  A61K31/00 ,  A61K38/2278 ,  Y10S514/866

    摘要： Methods for increasing urine flow are disclosed, comprising administration of an effective amount of GLP-1, an exendin, or an exendin or GLP-1 agonist. Methods for increasing urinary sodium excretion and decreasing urinary potassium concentration are also disclosed. The methods are useful for treating conditions or disorders associated with toxic hypervolemia, such as renal failure, congestive heart failure, nephrotic syndrome, cirrhosis, pulmonary edema, and hypertension. The present invention also relates to methods for inducing an inotropic response comprising administration of an effective amount of GLP-1, an exendin, or an exendin or GLP-1 agonist. These methods are useful for treating conditions or disorders that can be alleviated by an increase in cardiac contractility such as congestive heart failure. Pharmaceutical compositions for use in the methods of the invention are also disclosed.

    摘要翻译： 公开了增加尿流量的方法，包括施用有效量的GLP-1，毒蜥外泌肽或毒蜥外泌肽或GLP-1激动剂。 还公开了增加尿钠排泄量和降低尿钾浓度的方法。 该方法可用于治疗与毒性高血容量相关的病症或病症，例如肾衰竭，充血性心力衰竭，肾病综合征，肝硬化，肺水肿和高血压。 本发明还涉及诱导肌力反应的方法，包括施用有效量的GLP-1，毒蜥外泌肽或毒蜥外泌肽或GLP-1激动剂。 这些方法可用于治疗可通过增加心脏收缩力如充血性心力衰竭而减轻的病症或障碍。 还公开了用于本发明方法的药物组合物。

    Modified exendins and exendin agonists
    4.
    发明申请
    Modified exendins and exendin agonists 有权
    改良的毒蜥外泌肽和毒蜥外泌激素

    公开(公告)号：US20050267034A1

    公开(公告)日：2005-12-01

    申请号：US11174089

    申请日：2005-06-30

    申请人： Kathryn Prickett ,  Andrew Young

    发明人： Kathryn Prickett ,  Andrew Young

    IPC分类号： A61K38/22 ,  A61K47/48 ,  C07K14/47

    CPC分类号： C07K14/605 ,  A61K47/60

    摘要： Novel modified exendins and exendin agonists having an exendin or exendin agonist linked to one or more polyethylene glycol polymers, for example, and related formulations and dosages and methods of administration thereof are provided. These modified exendins and exendin agonists, compositions and methods are useful in treating diabetes and conditions that would be benefited by lowering plasma glucose or delaying and/or slowing gastric emptying or inhibiting food intake.

    摘要翻译： 提供了具有与一种或多种聚乙二醇聚合物连接的毒蜥外泌肽或毒蜥外泌激素的新型修饰的毒蜥外泌肽和毒蜥外泌肽激动剂，以及相关的制剂和剂量以及施用方法。 这些修饰的毒蜥外泌肽和毒蜥外泌肽激动剂，组合物和方法可用于治疗通过降低血浆葡萄糖或延迟和/或减缓胃排空或抑制食物摄取而受益的糖尿病和病症。

    Use of exendins and agonists thereof for the reduction of food intake
    6.
    发明申请
    Use of exendins and agonists thereof for the reduction of food intake 有权
    使用毒蜥外泌肽及其激动剂来减少食物摄入

    公开(公告)号：US20060148713A1

    公开(公告)日：2006-07-06

    申请号：US11368225

    申请日：2006-03-03

    申请人： Nigel Robert Beeley ,  Kathryn Prickett ,  Sunil Bhavsar ,  Andrew Young

    发明人： Nigel Robert Beeley ,  Kathryn Prickett ,  Sunil Bhavsar ,  Andrew Young

    IPC分类号： A61K38/22

    CPC分类号： A61K9/0019 ,  A61K38/00 ,  A61K38/22 ,  A61K38/2207 ,  A61K38/2264 ,  A61K38/23 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/26 ,  A61K47/44 ,  C07K14/57563 ,  Y10S514/866 ,  A61K2300/00

    摘要： Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist, alone or in conjunction with other compounds or compositions that affect satiety. The methods are useful for treating conditions or disorders, including obesity, Type II diabetes, eating disorders, and insulin-resistance syndrome. The methods are also useful for lowering the plasma glucose level, lowering the plasma lipid level, reducing the cardiac risk, reducing the appetite, and reducing the weight of subjects. Pharmaceutical compositions for use in the methods of the invention are also disclosed.

    摘要翻译： 公开了通过减少食物摄入可以缓解的病症或病症的方法，其包括单独施用有效量的毒蜥外泌肽或毒蜥外泌肽激素，或与影响饱腹感的其它化合物或组合物联合施用。 该方法可用于治疗条件或障碍，包括肥胖，II型糖尿病，进食障碍和胰岛素抵抗综合征。 该方法对于降低血浆葡萄糖水平，降低血浆脂质水平，降低心脏风险，降低食欲和降低受试者的体重也是有用的。 还公开了用于本发明方法的药物组合物。

    DISTENDER DEVICE AND METHOD FOR TREATMENT OF OBESITY AND METABOLIC AND OTHER DISEASES
    7.
    发明申请
    DISTENDER DEVICE AND METHOD FOR TREATMENT OF OBESITY AND METABOLIC AND OTHER DISEASES 审中-公开
    用于治疗肥胖和代谢疾病及其他疾病的减轻器具及方法

    公开(公告)号：US20110202083A1

    公开(公告)日：2011-08-18

    申请号：US13095014

    申请日：2011-04-27

    申请人： Andrew Young

    发明人： Andrew Young

    IPC分类号： A61F2/04

    CPC分类号： A61F5/0076 ,  A61F2/04

    摘要： A gastrointestinal implant device is positioned in a patient's small intestine or rectum and produces an outward force that itself produces a distension signal which is a therapeutically useful neural or humoral signal that evokes satiogenic or weight loss effects by itself. The device may advantageously be placed in the duodenum adjacent the pylorus or in the jejunum, ileum or rectum. The distension signals may amplify chemosensory or mechanosensory signals such as enteroendocrine secretions within the patient. The device may be a mesh and include a low material density that allows for unrestricted chyme absorption within the small intestine and unrestricted chyme flow through the gastrointestinal system. A method includes inserting the device into the patient then either retrieving the device after treatment is complete or allowing a device formed of a biodegradable material to degrade in time after treatment is complete.

    摘要翻译： 胃肠道植入装置定位在患者的小肠或直肠中，并产生向外的力，其本身产生膨胀信号，其是治疗上有用的神经或体液信号，其本身唤起饱腹感或体重减轻作用。 该装置可以有利地放置在邻近幽门或在空肠，回肠或直肠中的十二指肠中。 膨胀信号可以放大患者体内的化学感觉或机械感觉信号，如肠内分泌分泌物。 该装置可以是网状物并且包括低材料密度，其允许在小肠内不受限制的食糜吸收和通过胃肠系统的不受限制的食糜流。 一种方法包括将装置插入患者，然后在治疗完成之后取回装置，或允许由可生物降解的材料形成的装置在治疗完成后在时间上降解。

    Computer Methods And Apparatus For Optimizing Portfolios Of Multiple Participants
    8.
    发明申请
    Computer Methods And Apparatus For Optimizing Portfolios Of Multiple Participants 有权
    用于优化多个参与者组合的计算机方法和装置

    公开(公告)号：US20070150399A1

    公开(公告)日：2007-06-28

    申请号：US11668279

    申请日：2007-01-29

    申请人： Andrew Young ,  Evan Tick ,  Robert Towse ,  Yoon Chang ,  Roy Campbell ,  Joan Tse ,  Stephen Reddy ,  Young-Sup Lee ,  John Scowcroft

    发明人： Andrew Young ,  Evan Tick ,  Robert Towse ,  Yoon Chang ,  Roy Campbell ,  Joan Tse ,  Stephen Reddy ,  Young-Sup Lee ,  John Scowcroft

    IPC分类号： G06Q40/00

    CPC分类号： G06Q40/00 ,  G06Q40/04 ,  G06Q40/06

    摘要： Computer technology for substantially optimizing portfolios of multiple participants is disclosed. Preferably the portfolios of such multiple participants comprise fixed income instruments. The disclosed systems and methods include using at least one computer system for storing digital data representing portfolio holdings of multiple parties and, in particular, for each participant storing in the computer memory data representing constraints with respect to the desired portfolio. The method and system comprise optimizing using an optimization engine portfolio and constraint information of multiple participants so as to generate a set of trades that would substantially optimize participants portfolios with respect to a known objective.

    摘要翻译： 公开了大量优化多个参与者组合的计算机技术。 优选地，这种多个参与者的投资组合包括固定收益工具。 所公开的系统和方法包括使用至少一个计算机系统来存储表示多方的投资组合持有的数字数据，并且特别地，对于存储在表示对于期望投资组合的约束的计算机存储器中的每个参与者而言。 该方法和系统包括使用优化引擎组合和多个参与者的约束信息进行优化，以便产生一组相对于已知目标大大优化参与者组合的交易。