公开(公告)号：US20090005659A1

公开(公告)日：2009-01-01

申请号：US12181192

申请日：2008-07-28

申请人： Nikiforos Kollias ,  Ying Sun ,  Coston Anthony F.

发明人： Nikiforos Kollias ,  Ying Sun ,  Coston Anthony F.

IPC分类号： A61B5/00 ,  A61N1/30

CPC分类号： A61N1/303

摘要： A shear device for use in transporting a molecule through a mammal's mammalian barrier membrane of at least one layer of cells includes a sheet containing an opening(s) and a shear member(s). The sheet is configured for contacting the mammalian barrier membrane (e.g., human skin) and the shear member is configured for ablating a portion of the mammalian barrier membrane forced through the opening(s). This ablating is accomplished by movement of the shear member(s) over the sheet and the opening(s). The ablation of the portion of the mammalian barrier membrane is such that a driving force can be employed to transport the molecule therethrough.

摘要翻译： 用于通过哺乳动物的至少一层细胞的哺乳动物屏障膜输送分子的剪切装置包括含有开口和剪切构件的片材。 该片被配置用于接触哺乳动物屏障膜（例如，人皮肤），并且剪切构件被配置用于烧蚀被迫穿过开口的哺乳动物屏障膜的一部分。 这种消融是通过剪切构件在片材和开口上的移动来实现的。 哺乳动物屏障膜部分的消融使得可以采用驱动力来输送分子。