利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

3 条记录 (耗时 0.023 秒)

    Crystal structure of a deacetylase and inhibitors thereof
    1.
    发明申请
    Crystal structure of a deacetylase and inhibitors thereof 审中-公开
    脱乙酰酶的晶体结构及其抑制剂

    公开(公告)号：US20070087427A1

    公开(公告)日：2007-04-19

    申请号：US11505214

    申请日：2006-08-16

    申请人： Nikola Pavletich ,  Michael Finnin ,  Jill Donigian ,  Victoria Richon ,  Richard Rifkind ,  Paul Marks ,  Ronald Breslow

    发明人： Nikola Pavletich ,  Michael Finnin ,  Jill Donigian ,  Victoria Richon ,  Richard Rifkind ,  Paul Marks ,  Ronald Breslow

    IPC分类号： C12N9/18 ,  G06F19/00

    CPC分类号： C12N9/16

    摘要： The present invention provides three-dimensional structural information from the hyperthermophilic bacterium Aquifex aeolicus which is a histone deacetylase-like protein (HDLP). HDLP shares 35.2% amino acid sequence identity with human histone deacetylase (HDAC1). The present invention further provides three-dimensional structural information of HDLP bound by inhibitor molecules. The three-dimensional structural information of the present invention is useful to design, isolate and screen deacetylase inhibitor compounds capable of inhibiting HDLP, HDAC family members and HDLP-related molecules. The invention also relates to nucleic acids encoding a mutant HDLP which facilitates the determination of the three-dimensional structure of HDLP in the presence of a zinc atom.

    摘要翻译： 本发明提供来自作为组蛋白脱乙酰酶样蛋白质（HDLP）的超嗜热菌Aquifex aeolicus的三维结构信息。 HDLP与人组蛋白脱乙酰酶（HDAC1）具有35.2％的氨基酸序列同一性。 本发明还提供了由抑制剂分子结合的HDLP的三维结构信息。 本发明的三维结构信息可用于设计，分离和筛选能够抑制HDLP，HDAC家族成员和HDLP相关分子的脱乙酰酶抑制剂化合物。 本发明还涉及编码突变型HDLP的核酸，其有助于在锌原子存在下测定HDLP的三维结构。