公开(公告)号：US08321013B2

公开(公告)日：2012-11-27

申请号：US11933168

申请日：2007-10-31

申请人： Nissim Darvish ,  Bella Felsen ,  Itzhak Shemer ,  Judith Kornfeld ,  Shlomo Ben-Haim ,  Maier Fenster ,  Yuval Mika

发明人： Nissim Darvish ,  Bella Felsen ,  Itzhak Shemer ,  Judith Kornfeld ,  Shlomo Ben-Haim ,  Maier Fenster ,  Yuval Mika

IPC分类号： A61N1/00

CPC分类号： A61N1/3627 ,  A61N1/05 ,  A61N1/0587 ,  A61N1/36514 ,  A61N1/36564

摘要： A method of modifying the force of contraction of at least a portion of a heart chamber is provided. A non-excitatory electric field of given duration is applied, at a delay after an activation of the heart, which increase the force of contraction by at least 5%. Apparatus is also provided for pacing with hemodynamic improvement. Circuitry applies an extended pacing signal to electrodes to pace the heart, the extended pacing signal having an overall duration greater than 8 ms from a time of initiation of application of that portion of the signal that initiates action potential propagation. The signal includes a train of biphasic pulses having pulse durations of at least 1 ms, and the signal has an amplitude that is at least three times as great as a threshold for pacing the heart and that is sufficient neither for cardioversion nor for defibrillation. Other embodiments are also described.

摘要翻译： 提供了改变心室的至少一部分的收缩力的方法。 给予持续时间的非兴奋性电场在心脏激活后延迟施加，其将收缩力增加至少5％。 还提供了用于具有血液动力学改善的起搏的装置。 电路将扩展的起搏信号施加到电极以对心脏进行调节，所述扩展起搏信号的总持续时间大于从启动动作电位传播的信号部分开始施加的时间大于8ms。 该信号包括具有至少1ms的脉冲持续时间的两列脉冲，并且该信号具有至少三倍于起搏心脏阈值的幅度，并且既不适用于心脏复律也不适用于除颤。 还描述了其它实施例。

公开(公告)号：US07460907B1

公开(公告)日：2008-12-02

申请号：US09720639

申请日：1999-07-18

申请人： Nissim Darvish ,  Bella Felsen ,  Itzik Shemer ,  Judith Kornfeld

发明人： Nissim Darvish ,  Bella Felsen ,  Itzik Shemer ,  Judith Kornfeld

IPC分类号： A61N1/362

CPC分类号： A61N1/362 ,  A61N1/3627

摘要： Apparatus (170) for heart pacing with hemodynamic improvement, including one or more electrodes (36), which convey electrical signals to respective cardiac muscle segments. Signal generation circuitry (50) applies an extended pacing signal (60, 61), having an overall duration greater than three times a chronaxie time, to the one or more electrodes so as to pace the heart. The signal preferably includes a train of a plurality of biphasic pulses, and has an amplitude at least three times as great as a threshold for pacing the heart, but not sufficient for cardioversion.

摘要翻译： 用于具有血流动力学改善的心脏起搏的装置（170），包括将电信号传送到相应心肌段的一个或多个电极（36）。 信号发生电路（50）将具有大于时间三倍的总持续时间的扩展起搏信号（60,61）施加到所述一个或多个电极，以便心跳。 信号优选地包括多个双相脉冲串，并且具有至少三倍于用于起搏心脏的阈值的振幅，但不足以用于心脏复律。

公开(公告)号：US07412289B2

公开(公告)日：2008-08-12

申请号：US09849637

申请日：2001-05-04

申请人： Dov Malonek ,  Nissim Darvish ,  Judith Kornfeld

发明人： Dov Malonek ,  Nissim Darvish ,  Judith Kornfeld

IPC分类号： A61N1/05

CPC分类号： A61N1/05 ,  A61N1/0587 ,  A61N2001/0585

摘要： This invention is a lead (10) for modifying the activity of a tissue, particularly the heart. Electrodes are provided for performing sensing (15p) (15d), and/or signal delivery (16p) (16d) functions. A control unit controls the parameters of the electric field provided by signal delivery electrodes to prevent the generation of a propagation action potential in the tissue.

摘要翻译： 本发明是用于改变组织，特别是心脏的活性的引线（10）。 提供用于执行感测（15p）（15d）和/或信号传递（16p）（16d）功能的电极。 控制单元控制由信号传送电极提供的电场的参数，以防止在组织中产生传播动作电位。