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公开(公告)号:US20200157540A1
公开(公告)日:2020-05-21
申请号:US16685283
申请日:2019-11-15
发明人: Bharat Majeti , Jean-Pierre Clamme , Li Wang , Roger C. Adami , Wenbin Ying
IPC分类号: C12N15/113 , A61P35/00 , A61K31/712 , A61K31/7125 , A61K47/28 , A61K47/24 , A61K9/14 , A61K9/19 , A61K9/16
摘要: This invention provides formulations for use in distributing RNAi molecules targeted to a human GST-π for treating a malignant tumor in a subject. The formulation can include nanoparticles composed of an ionizable lipid, a DSPE lipid, and additional lipids. A drug product can be made by lyophilization of the formulation. This invention further provides methods for ameliorating or treating a malignant tumor by administering a therapeutically effective amount of a formulation containing the RNAi agents.